Revealing the role of serum exosomal novel long non-coding RNA NAMPT-AS as a promising diagnostic/prognostic biomarker in colorectal cancer patients
Rizk, Nehal I; Kassem, Dina; Abulsoud, Ahmed I; AbdelHalim, Sherif; Yasser, Montaser Bellah; Kamal, Mohamed M; Hamdy, Nadia M;
Abstract
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Nicotinamide phosphoribosyl-transferase (NAMPT) was found to be over-expressed in several cancers including CRC. NAMPT-Antisense (NAMPT-AS) is a novel long non-coding RNA (lncRNA) recently reported to be associated with triple negative breast cancer. However, its role in CRC has not been investigated. This study was designed to explore the role of lncRNA NAMPT-AS in CRC, and to investigate its circulating serum exosomal levels in subjects with/without CRC.
Other data
| Title | Revealing the role of serum exosomal novel long non-coding RNA NAMPT-AS as a promising diagnostic/prognostic biomarker in colorectal cancer patients | Authors | Rizk, Nehal I; Kassem, Dina ; Abulsoud, Ahmed I; AbdelHalim, Sherif; Yasser, Montaser Bellah; Kamal, Mohamed M; Hamdy, Nadia M | Keywords | Colorectal cancer;Exosomes;Extracellular vesicles;Long non-coding RNA;NAMPT;NAMPT-antisense | Issue Date | 18-Jun-2024 | Journal | Life Sciences | Volume | 352 | ISSN | 00243205 | DOI | 10.1016/j.lfs.2024.122850 | PubMed ID | 38901687 |
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