Silencing of forkhead box protein O-1 (FOXO-1) enhances insulin-producing cell generation from adipose mesenchymal stem cells for diabetes therapy
Kamal, Mohamed M; Ammar, Reham A; Kassem, Dina;
Abstract
Generation of mature β-cells from MSCs has been a challenge in the field of stem cell therapy of diabetes. Adipose tissue-derived mesenchymal stem cells (Ad-MSCs) have made their mark in regenerative medicine, and provide several advantages compared to other MSCs sources. Forkhead box protein O-1 (FOXO-1) is an important transcription factor for normal development of β-cells, yet its over expression in β-cells may cause glucose intolerance. In this study, we isolated, characterized Ad-MSCs from rat epididymal fat pads, differentiated these MSCs into insulin producing cells (IPCs) and studied the role of FOXO-1 in such differentiation.
Other data
| Title | Silencing of forkhead box protein O-1 (FOXO-1) enhances insulin-producing cell generation from adipose mesenchymal stem cells for diabetes therapy | Authors | Kamal, Mohamed M; Ammar, Reham A; Kassem, Dina | Keywords | Adipose;Cell therapy;Diabetes mellitus;FOXO-1;Insulin producing cells;Mesenchymal stem cells;Regenerative medicine | Issue Date | 1-May-2024 | Publisher | Elsevier | Journal | Life Sciences | Volume | 344 | Start page | 122579 | ISSN | 00243205 | DOI | 10.1016/j.lfs.2024.122579 | PubMed ID | 38518842 | Scopus ID | 2-s2.0-85188828962 |
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