Lipid profile and levels of homocysteine and total antioxidant capacity in plasma of rats with experimental thyroid disorders
saleh, afaf;
Abstract
This study focuses on the relationship between serum levels of cholesterol and homocys-teine with that of total antioxidant capacity in rats with thyroid dysfunction.
Adult male Wistar rats were divided into three groups, a control (euthyroid), hypothyroidism and
hyperthyroidism, each of them containing ten rats. Hypothyroidism was induced by administration
of 0.1% aminotriazole in drinking water for 3 weeks. Hyperthyroidism was induced by chronic
subcutaneous injection ofL-thyroxine (100lg/day, dissolved in 200lL saline solution/100 g body
weight) for 3 weeks. The control and hypothyroid groups were injected subcutaneously with the
same volume of saline solution.
Results showed that hyperthyroidism is characterized by reduced serum thyroid stimulating
hormone (TSH) levels despite increased free thyroxine (FT4) and free triiodothyronine (FT3
)
levels.
Significant (p< 0.05) elevation in serum levels of total homocysteine (t-Hcy) is reflected by a
decrease in serum total antioxidant capacity (TAC) production in hypothyroidism comparing to
control.
There was a significant (p< 0.05) elevation in serum levels of lipid profile (cholesterol, triglycer-ide and LDL) in hypothyroidism. Significant (p< 0.05) reduction occurred in the levels of choles-terol and triglyceride in hyperthyroidism. The association of hyperhomocysteinemia and lipid
abnormalities occurring in hypothyroidism may represent a dynamic atherogenic state
Adult male Wistar rats were divided into three groups, a control (euthyroid), hypothyroidism and
hyperthyroidism, each of them containing ten rats. Hypothyroidism was induced by administration
of 0.1% aminotriazole in drinking water for 3 weeks. Hyperthyroidism was induced by chronic
subcutaneous injection ofL-thyroxine (100lg/day, dissolved in 200lL saline solution/100 g body
weight) for 3 weeks. The control and hypothyroid groups were injected subcutaneously with the
same volume of saline solution.
Results showed that hyperthyroidism is characterized by reduced serum thyroid stimulating
hormone (TSH) levels despite increased free thyroxine (FT4) and free triiodothyronine (FT3
)
levels.
Significant (p< 0.05) elevation in serum levels of total homocysteine (t-Hcy) is reflected by a
decrease in serum total antioxidant capacity (TAC) production in hypothyroidism comparing to
control.
There was a significant (p< 0.05) elevation in serum levels of lipid profile (cholesterol, triglycer-ide and LDL) in hypothyroidism. Significant (p< 0.05) reduction occurred in the levels of choles-terol and triglyceride in hyperthyroidism. The association of hyperhomocysteinemia and lipid
abnormalities occurring in hypothyroidism may represent a dynamic atherogenic state
Other data
Title | Lipid profile and levels of homocysteine and total antioxidant capacity in plasma of rats with experimental thyroid disorders | Authors | saleh, afaf | Keywords | Homocysteine; Hypothyroidism; Hyperthyroidism; Lipid profile; Total antioxidant capacity; Rats | Issue Date | 1-Jan-2015 | Publisher | ELSEVIER B. V | Journal | Journal of basic and applied zoology | DOI | org/10.1016/j.jobaz.2015.01.001 |
Attached Files
File | Description | Size | Format | Existing users please Login |
---|---|---|---|---|
4.pdf | 442.65 kB | Adobe PDF | Request a copy | |
1.pdf | 389.69 kB | Unknown | Request a copy | |
2.pdf | 454.87 kB | Unknown | Request a copy | |
3.pdf | 468.77 kB | Unknown | Request a copy | |
4.pdf | 442.65 kB | Unknown | Request a copy | |
5.pdf | 1.02 MB | Unknown | Request a copy | |
6.pdf | 393.72 kB | Unknown | Request a copy | |
7.pdf | 682.73 kB | Unknown | Request a copy | |
8.pdf | 160.56 kB | Unknown | Request a copy | |
2013 Hany & Afaf.PDF | 329.58 kB | Unknown | Request a copy | |
Wulfenia .pdf | 1.63 MB | Unknown | Request a copy | |
Yassmen published paper.pdf | 1.25 MB | Unknown | Request a copy | |
1-s2.0-S209098961200029X-main.pdf | 303.13 kB | Unknown | Request a copy | |
tempelate Obesity.doc | 283 kB | Unknown | Request a copy | |
template R.F.doc | 158 kB | Unknown | Request a copy |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.