Lipid Profile and Some Hormonal Disorders in Serum of High-Fat Diet Fed Rats
Hany Nady Yousef; saleh, afaf;
Abstract
Background: Chronic consumption of high-fat diet (HFD) induces obesity. The purpose of the
current study was to evaluate the impact of high-fat diet-induced obesity on lipid profile and levels of
certain hormones in male albino rats.
Material and Methods: A total of forty two 12-week old male albino rats were divided into three
groups: control group fed a normal diet, obese group I fed 25% HFD and obese group II fed 50%
HFD. Each group was divided into two subgroups (seven rats for each) feeding on the corresponding
diet for four and eight weeks. Serum total cholesterol (TC), triglycerides (TG), high density
lipoprotein cholesterol (HDL-Chol), low density lipoprotein cholesterol (LDL-Chol), free
Triiodothyronine (FT3), free Thyroxine (FT
4), Insulin, Leptin and Adiponectin were assessed at the
end of 4
th
and 8
th
weeks. Also LDL/HDL-cholesterol ratios of control and obese groups were
calculated at the same time intervals.
Results: The obtained results indicated significant increase in all parameters of serum lipid profiles in
addition to elevation of the LDL/HDL-cholesterol ratios of obese rats compared to those of the
controls. In response to HFD, marked increase was recorded in the levels of insulin and leptin while
values of FT
3 and adiponectin were reduced significantly. On the other hand, HFD did not change the
levels of FT
4. Most of the recorded changes were more obvious by increasing either the percentage of
fats or the feeding period.
Conclusion: In conclusion, HFD induces some hormonal disorders accompanied by disturbance of
the lipid profile.
current study was to evaluate the impact of high-fat diet-induced obesity on lipid profile and levels of
certain hormones in male albino rats.
Material and Methods: A total of forty two 12-week old male albino rats were divided into three
groups: control group fed a normal diet, obese group I fed 25% HFD and obese group II fed 50%
HFD. Each group was divided into two subgroups (seven rats for each) feeding on the corresponding
diet for four and eight weeks. Serum total cholesterol (TC), triglycerides (TG), high density
lipoprotein cholesterol (HDL-Chol), low density lipoprotein cholesterol (LDL-Chol), free
Triiodothyronine (FT3), free Thyroxine (FT
4), Insulin, Leptin and Adiponectin were assessed at the
end of 4
th
and 8
th
weeks. Also LDL/HDL-cholesterol ratios of control and obese groups were
calculated at the same time intervals.
Results: The obtained results indicated significant increase in all parameters of serum lipid profiles in
addition to elevation of the LDL/HDL-cholesterol ratios of obese rats compared to those of the
controls. In response to HFD, marked increase was recorded in the levels of insulin and leptin while
values of FT
3 and adiponectin were reduced significantly. On the other hand, HFD did not change the
levels of FT
4. Most of the recorded changes were more obvious by increasing either the percentage of
fats or the feeding period.
Conclusion: In conclusion, HFD induces some hormonal disorders accompanied by disturbance of
the lipid profile.
Other data
Title | Lipid Profile and Some Hormonal Disorders in Serum of High-Fat Diet Fed Rats | Authors | Hany Nady Yousef ; saleh, afaf | Issue Date | Jul-2013 | DOI | 10.12816/0000598 |
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