Effectiveness of Nano L-Carnitine and Thyroxin in the management ofhypothyroidism in male rats

Abstract

This study was planned to explore the role of L-carnitine and its nanoparticles against carbimazole(CB) induced hypothyroidism in male rats. Rats divided into 5 groups; G(1): negative control, G(2): hypothyroid group orally administered 0.03% (w/v) CB, G(3): L-carnitine(LC) treated group orally administered 500 mg/kg of (LC) after induction of hypothyroidism , G(4): L- carnitine nanoform(LCN) treated group orally administered 50 mg/kg after induction of hypothyroidism , G(5): Eltroxin (T4) treated group orally administered with 9μgm /kg bw after induction of hypothyroidism. The results showed that LC and LCN treatment significantly (P<0.05) increased both the thyroid hormones triiodothyronine (T3) and thyroxine (T4) with a concomitant decrease in LPO and thyroid stimulating hormone (TSH) levels, suggesting their thyroid stimulatory and antioxidative role. Also, treatment with (LC) and (LCN) reduced the elevations in total cholesterol (TC), triglyceride (TG) and Low Density Lipoprotein (LDL-C), oxidized glutathione (GSSG) as well as nitric oxide (NO) and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Moreover, antioxidant defense enzymes, Liver cell energy adenosine di-phosphate (ADP) and adenosine monophosphate (AMP) and brain serotonin (5HT) levels significantly increased compared to hypothyroid and control groups. The results obtained suggest that (LCN) is a powerful antioxidant therapy may prove beneficial and curative effect against hypothyroidism.