Evaluation of MicroRNA-210 and Protein tyrosine phosphatase, non-receptor type 2 in Pre-eclampsia

Adel, S. ; Mansour, A. ; Louka, M. ; Matboli, M. ; Elmekkawi, S.F. ; Swelam, N. 


Abstract


The precise origin of Pre-eclampsia (PE) remains elusive. Multiple pieces of evidence support the existence of hypoxia in PE. MiRNA-210 (miR-210), which is induced by Hypoxia-Inducible Factor-1α (HIF-1α) during hypoxia, is one of the most hypoxia sensitive miRNAs. MiR-210 mediates these functions by regulating a lot of target mRNAs. Protein tyrosine phosphatase, non-receptor type 2 (PTPN2) was one of miR-210 targets and was found to be down regulated by hypoxia.


Other data

Issue Date 2017
Journal Gene 
URI http://research.asu.edu.eg/123456789/245
DOI 105-109
http://www.scopus.com/inward/record.url?eid=2-s2.0-84994246885&partnerID=MN8TOARS
596
1879-0038
10.1016/j.gene.2016.10.014


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