Neuropsychological impairments across unmedicated acutely-ill and medicated remitted phases of bipolar I disorder
Lotaief Farouk., Refaat Ghada., Khalifa Doaa., El-Sheikh Mona., Zaki Nivert. and Hewedi Doaa;
Abstract
Previous research has demonstrated neuropsychological impairments in bipolar disorder. Only
few studies compared cognitive functions across different clinical states of bipolar disorder.
To investigate and verify the patterns of cognitive dysfunction in the different phases of
bipolar disorder and to find out the relationship between clinical features and cognitive
impairments. Four groups; 28 manic, 21 depressed, 25 euthymic patients and 20 healthy
control were administered a brief battery of neuropsychological tests for assessment of
attention, executive function, visual and verbal memory. All bipolar groups showed poorer
neuropsychological performance in all tests compared to the control group. The 3 bipolar
groups showed some distinct pattern in types and severity of cognitive impairments. Patients
with longer duration of illness, early onset, greater number of episodes and with history of
psychotic features were found to show poorer performance. Cognitive impairments are
present across all phases of bipolar disorder. Although they seem to be genuine in nature, they
are influenced by chronicity of illness, frequency of episodes and psychiatric symptoms.
few studies compared cognitive functions across different clinical states of bipolar disorder.
To investigate and verify the patterns of cognitive dysfunction in the different phases of
bipolar disorder and to find out the relationship between clinical features and cognitive
impairments. Four groups; 28 manic, 21 depressed, 25 euthymic patients and 20 healthy
control were administered a brief battery of neuropsychological tests for assessment of
attention, executive function, visual and verbal memory. All bipolar groups showed poorer
neuropsychological performance in all tests compared to the control group. The 3 bipolar
groups showed some distinct pattern in types and severity of cognitive impairments. Patients
with longer duration of illness, early onset, greater number of episodes and with history of
psychotic features were found to show poorer performance. Cognitive impairments are
present across all phases of bipolar disorder. Although they seem to be genuine in nature, they
are influenced by chronicity of illness, frequency of episodes and psychiatric symptoms.
Other data
| Title | Neuropsychological impairments across unmedicated acutely-ill and medicated remitted phases of bipolar I disorder | Authors | Lotaief Farouk., Refaat Ghada., Khalifa Doaa., El-Sheikh Mona., Zaki Nivert. and Hewedi Doaa | Issue Date | 2007 | Journal | Current Psychiatry | ISSN | 1687-7802 |
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