Platelet-derived microparticles and platelet function profile in children with congenital heart disease

Ismail E. ; Youssef O. 


Abstract


Platelet microparticles (PMPs) and function profile in children with congenital heart disease (CHD) have not been widely explored. We investigated platelet aggregation, flow cytometric platelet surface receptors (P-selectin and glycoprotein (GP) IIb/IIIa) and PMPs in 23 children with cyanotic CHD (CCHD), 30 children with acyanotic CHD (ACHD) and 30 healthy controls correlating these variables to hematological and coagulation parameters including von Willebrand factor antigen (vWF Ag) as a marker of endothelial dysfunction. Hemoglobin, hematocrit (HCT), d-dimer, and vWF Ag were significantly higher in CCHD than ACHD group. Platelet MPs and P-selectin expression were increased in patients than controls, particularly in CCHD and positively correlated to HCT, d-dimer, and vWF Ag while platelet count, aggregation, and GP IIb/IIIa expression were decreased in CCHD compared with ACHD group and negatively correlated to HCT. The overproduction of PMPs and platelet activation with suppressed aggregation may be implicated in the pathogenesis of coagulation/hemostatic abnormalities in children with CCHD. © 2012 The Author(s).


Other data

Issue Date 1-Jul-2013
Journal Clinical and Applied Thrombosis/Hemostasis 
URI http://research.asu.edu.eg/123456789/458
DOI 4
424
http://api.elsevier.com/content/abstract/scopus_id/84879910220
19
1938-2723
10.1177/1076029612456733


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