Ameliorative effects of Artemisia judaica L. extract against alloxan-induced biochemical alterations in male wistar rats

EMAN G.E. HELAL ; NOURAN ABOU-AOUF ; HANY NADY YOUSEF ; FATIMAH M YOUSEF ; AL SAYEDA MOHAMMAD KHATTAB 


Abstract


Objective: The current study aims to evaluate the potential of crude leaf extract of Artemisia judaica L. (AJE) in reducing the biochemical abnormalities accompanied to alloxan-induced diabetes in male Wistar rats. Methods: Thirty male albino rats (100-110 g) were divided equally into three groups including control, diabetic and diabetic+AJE. Diabetes was induced by using a single dose of alloxan (120 mg/kg of body weight). Serum biochemical parameters, including insulin, glucose, triglycerides, total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), very low density lipoprotein cholesterol (VLDL), total proteins, albumin, globulin, renal markers (creatinine, urea, uric acid), activities of aspartate transaminase (AST), alanine transaminase (ALT) and gamma-glutamyltransferase (ɤGT) were measured in all groups. Also, values of homeostasis model assessment of insulin resistance (HOMA-IR) and ratios of albumin: globulin (A: G), TC/HDL (risk factor-1), LDL/HDL (risk factor-2) were calculated for each group. Results: Diabetic rats showed reduction in body weight and marked decline in the values of serum insulin, protein profile indices and HDL accompanied with marked elevation in values of glucose, HOMA_IR, triglycerides, TC, LDL, VLDL, TC/HDL, LDL/HDL, renal markers and activities of the estimated enzymes. Supplementation of diabetic rats with AJE, twice daily for 30 days, significantly ameliorated most of the estimated biochemical parameters. Conclusion: The current results demonstrate that AJE possesses a hypoglycemic effect and acts as a protective factor against metabolic abnormalities induced by diabetes mellitus.


Other data

Keywords Artemisia judaica, Alloxan, Diabetes, Lipid profile, Renal markers, Hyperglycemia
Issue Date 2015
Journal International Journal of Pharmacy and Pharmaceutical Sciences 
URI http://www.scopus.com/inward/record.url?eid=2-s2.0-84940657314&partnerID=MN8TOARS
https://innovareacademics.in/journals/index.php/ijpps/article/view/7038
http://research.asu.edu.eg/123456789/492


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