Synthesis and cytotoxicity evaluation of some novel chromone annulated phosphorus heterocycles

Somaya M. El-Edfawy ; S. M. El-Edfawy ; S. EL-EDFAWY 


Abstract


Novel chromono[2,3-e][1,2,4,3]triazaphosphepines 3−7, chromono[2,3-d][1,3,2]diazaphosphinine 8, chromonyl α-hydrazinophosphonic acid 10, chromono[3,2-d][1,2]azaphosphole 11 and diethyl N-chromonylphosphonoacetamide 12 were synthesized from treatment of 2-amino-3-[(2-phenylhydrazinylidene) methyl]chromone (2) with some phosphorus reagents such as phosphorus halides, phosphorus sulfides, and phosphonic acid and its diesters, in dry dioxane. The cytotoxic effects of the synthesized compounds were evaluated in vitro in relation to hepatocellular Hep-G2, breast MCF-7 and colon HCT-116 human cancer cell lines, using a crystal violet viability assay. Compounds 6, 7, 8, and 10 had significant cytotoxic effects against the three cancer cell lines. Their IC50 values ranged between 1.56 and 12.4 μg/mL in comparison to doxorubicin (IC50 = 0.426-0.469 μg/mL).


Other data

Keywords Chromone; hydrazone; triazaphosphole; triazaphosphinine; triazaphosphepine; cytotoxicity
Issue Date 2017
Publisher Taylor&Frances
URI http://research.asu.edu.eg/123456789/498


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