Ameliorative role of camel whey protein and rosuvastatin on induced dyslipidemia in mice

El-Shinnawy, N.A. ; Haggag, N.Z. ; Badr, G. ; Abd-Elhalem, Sahar Sobhy 


Abstract


The incidence of obesity is rapidly increasing throughout the world. Dyslipidemia is a major risk factor for a number of chronic diseases, including diabetes and cardiovascular diseases. This work presents a novel approach to study the activity of camel whey protein (WP) with antioxidant and anti-inflammatory properties as a cheap dietary protein substance extracted from camel milk to produce satiety and help in building muscles. Mice model suffering from dyslipidemia as a result of feeding on high fat-cholesterol diet for 8 weeks were administrated with either camel WP and/or rosuvastatin for 4 weeks. Dyslipidemia revealed significant increase in anthropometrical measurements, levels of glucose, insulin, cholesterol, triglycerides, low-density lipoprotein, total leucocyte count, inflammatory cytokines and reactive oxygen species, accompanied by a significant elevation in activating transcription factor-3 and inducible nitric oxide synthase expressions. These alterations were correlated with a profound reduction in high-density lipoprotein, peroxisome proliferator-activated receptor alpha and adiponectin along with a decrease in liver and muscle mitochondrial proteins. Rosuvastatin treatment to mice suffering from dyslipidemia in combination with camel WP for 4 weeks ameliorated these parameters. Notably, animals treated with both camel WP and rosuvastatin exhibited a remarkable decrease in the incidence of dyslipidemia. In addition, camel WP succeeded to overcome the therapeutic drawback posed from rosuvastatin therapy alone with minimal side effects.


Other data

Issue Date Jan-2018
Publisher Royal Society of Chemistry
Journal Food and Function 
URI http://research.asu.edu.eg/123456789/507
DOI 2
1038-1047
http://www.scopus.com/inward/record.url?eid=2-s2.0-85042476870&partnerID=MN8TOARS
9
2042-650X
10.1039/c7fo01871a


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