Ameliorative role of camel whey protein and rosuvastatin on induced dyslipidemia in mice
El-Shinnawy, N.A.; Haggag, N.Z.; Badr, G.; Abd-Elhalem, Sahar Sobhy;
Abstract
The incidence of obesity is rapidly increasing throughout the world. Dyslipidemia is a major risk factor for a number of chronic diseases, including diabetes and cardiovascular diseases. This work presents a novel approach to study the activity of camel whey protein (WP) with antioxidant and anti-inflammatory properties as a cheap dietary protein substance extracted from camel milk to produce satiety and help in building muscles. Mice model suffering from dyslipidemia as a result of feeding on high fat-cholesterol diet for 8 weeks were administrated with either camel WP and/or rosuvastatin for 4 weeks. Dyslipidemia revealed significant increase in anthropometrical measurements, levels of glucose, insulin, cholesterol, triglycerides, low-density lipoprotein, total leucocyte count, inflammatory cytokines and reactive oxygen species, accompanied by a significant elevation in activating transcription factor-3 and inducible nitric oxide synthase expressions. These alterations were correlated with a profound reduction in high-density lipoprotein, peroxisome proliferator-activated receptor alpha and adiponectin along with a decrease in liver and muscle mitochondrial proteins. Rosuvastatin treatment to mice suffering from dyslipidemia in combination with camel WP for 4 weeks ameliorated these parameters. Notably, animals treated with both camel WP and rosuvastatin exhibited a remarkable decrease in the incidence of dyslipidemia. In addition, camel WP succeeded to overcome the therapeutic drawback posed from rosuvastatin therapy alone with minimal side effects.
Other data
Title | Ameliorative role of camel whey protein and rosuvastatin on induced dyslipidemia in mice | Authors | El-Shinnawy, N.A. ; Haggag, N.Z. ; Badr, G. ; Abd-Elhalem, Sahar Sobhy | Issue Date | Jan-2018 | Publisher | Royal Society of Chemistry | Journal | Food and Function | DOI | 2 1038-1047 http://www.scopus.com/inward/record.url?eid=2-s2.0-85042476870&partnerID=MN8TOARS 9 2042-650X 10.1039/c7fo01871a |
PubMed ID | 29349446 | Scopus ID | 2-s2.0-85042476870 |
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