THE SIDE EFFECTS OF DIABETES AND THE MODULATIVE ROLE OF OCIMUM GRATISSIMUM EXTRACT ON SOME BIOMARKERS OF FEMALE ALBINO RATS

Abstract

This study was conducted to elucidate the therapeutic modulative effects of herb Ocimum on alloxan-induced diabetic female rats. Adult female rats were divided into five groups :Control intact adult (G I).Control adult (positive control) injected with 75mg/kg body weight of Alloxan(G II).Adult hyperglycemic female rats treated with 200mg/kg body weight (low dose) of Ocimum(GIII).Adult hyperglycemic female rats treated with 400 mg/kg body weight (high dose) of Ocimum (GIV).Adult intact female rats injected with 200 mg/kg body weight (low dose) of Ocimum only (GV). A significant increase in serum glucose level in the control hyperglycemic group. Treatment with ocimum resulted in a highly significant improvement in serum glucose level. After treatment with ocimum a highly significant enhancement was observed in oestradiol hormone level, testosterone level, AST and ALT activities in all treated groups especially at high dose against in HB% and hematocrite. A highly significant improvement was achieved in serum total cholesterol and triglycerides concentrations in all treated groups especially at high dose. A slight changes was observed in calcium, phosphorus, total protein and albumin contents in serum in all treated groups but non significant.