Synthesis of new Schiff bases bearing 1,2,4-triazole, thiazolidine and chloroazetidine moieties and their pharmacological evaluation,.

Nadia G. Kandile, Mansoura I. Mohamed, Hind M. Ismaeel 


Abstract


ABSTRACT New compounds based on oxindole moiety were synthesized via the reaction of 5-substitued isatins 1a–e with different nucleophiles such as benzidine, 3,30 -dimethoxybenzidine 2a,b and 2,6-diaminopyridine 3 to afford three different classes of bis-Schiff bases 4a–e, 5a–e and 6a–e, respectively. The structures of the new compounds were elucidated on the basis of their FTIR, 1 H NMR, 13C NMR, GC/MS spectral data and elemental analysis. The in vitro antimicrobial activity of the new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration (MIC) against four bacterial and two fungal pathogens and anticancer activities against HELA cervix. The revealed data showed that compound 9d has excellent activity against Gram þ ve and Gram –ve bacteria, and compounds 11b presented promising anticancer activity against HELA cervix.


Other data

Keywords Anticancer drugs; minimal inhibitory concentration; oxindole moiety; pathagonic bacteria; Schiff bases;
Issue Date 2017
Publisher Taylor&Francis
Journal JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2017 VOL. 32, NO. 1, 119–129 
Series/Report no. http://dx.doi.org/10.1080/1;
Description ABSTRACT New compounds based on oxindole moiety were synthesized via the reaction of 5-substitued isatins 1a–e with different nucleophiles such as benzidine, 3,30 -dimethoxybenzidine 2a,b and 2,6-diaminopyridine 3 to afford three different classes of bis-Schiff bases 4a–e, 5a–e and 6a–e, respectively. The structures of the new compounds were elucidated on the basis of their FTIR, 1 H NMR, 13C NMR, GC/MS spectral data and elemental analysis. The in vitro antimicrobial activity of the new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration (MIC) against four bacterial and two fungal pathogens and anticancer activities against HELA cervix. The revealed data showed that compound 9d has excellent activity against Gram þ ve and Gram –ve bacteria, and compounds 11b presented promising anticancer activity against HELA cervix.
URI http://research.asu.edu.eg/123456789/545


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