Biochemical alterations in insecticides-treated male albino rats: Potential modulatory effects of a standardized aged garlic extract

Abstract

© 2017, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved. Pesticides poisoning is a major clinical problem worldwide. Malathion (an organophosphate insecticide) and carbaryl (a carbamate insecticide) are widely used and pose a potential health hazard for both humans and animals. They are common insecticides residue found in food, especially in developing countries. Here, we investigated some biochemical alterations related to dyslipidemia, tissue injury and the impairment in liver and kidney functions in male albino rats treated with 0.1 LD 50 of malathion (89.5 mg/kg body weight) and/or carbaryl (33.9 mg/kg body weight), as well as, evaluated the potential modulatory effects of 200 mg/kg body weight of a standardized odorless (free from allicin) Kyolic aged garlic extract (AGE, containing 0.147 % of its major active constituent S-allylcysteine) on the resulted toxicity. Doses were orally administered to animals for four consecutive weeks. The present study showed that AGE significantly alleviated (P < 0.05-0.001) most insecticides toxicity in rats through modulating the body-weight loss and hepatomegaly, blood dyslipidemia and the elevation in atherogenic indices, blood hyperbilirubinemia, hyperglycemia and hypoalbuminemia, the impairment in kidney function (by decreasing renal insecticides residue), and oxidative liver damage (by augmenting hepatic glutathione antioxidant-system). Thus, AGE may be useful as a dietary adjunct in highly vulnerable subjects to insecticides intoxication.