Synthesis and antitumor evaluation of novel tetrahydrobenzo[4′,5′]thieno[3′,2′:5,6]pyrimido[1,2-b]isoquinoline derivatives
Mahmoud M.; Abu El-Azm F.; Ismail M.; Hekal M.; Ali Y.; Hekal, Mohamed;
Abstract
© 2018 Taylor & Francis. In the present study, a novel 8,9,10,11-tetrahydro-7H,14H-benzo[4′,5′] thieno[2′,3′:4,5] -1,3-oxazino[3,2-b]isoquinoline-7,14-dione 5 was prepared by condensation of 2-amino-3-carbethoxy-4,5,6,7-tetrahydrobenzothiophene with homophthalic anhydride under microwave irradiation, followed by alkaline hydrolysis and cyclization using acetyl chloride. Compound 5 was further allowed to react with different nitrogen nucleophiles to get new tetrahydrobenzothienopyrimido isoquinolinone derivatives. The structures of the prepared compounds were elucidated by IR, 1 H-NMR, 13 C-NMR, and mass spectroscopy. The newly prepared compounds were tested in vitro against a panel of two human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2, and mammary gland breast MCF-7. Almost all the tested compounds showed satisfactory activity.
Other data
Title | Synthesis and antitumor evaluation of novel tetrahydrobenzo[4′,5′]thieno[3′,2′:5,6]pyrimido[1,2-b]isoquinoline derivatives | Authors | Mahmoud M. ; Abu El-Azm F. ; Ismail M. ; Hekal M. ; Ali Y. ; Hekal, Mohamed | Issue Date | 16-Feb-2018 | Journal | Synthetic Communications | DOI | 4 http://api.elsevier.com/content/abstract/scopus_id/85040978214 428 48 10.1080/00397911.2017.1406520 |
Scopus ID | 2-s2.0-85040978214 |
Attached Files
File | Description | Size | Format | |
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Synthesis and antitumor evaluation of novel tetrahydrobenzo 4 5 thieno 3 2 5 6 pyrimido 1 2 b isoquinoline derivatives.pdf | 1.14 MB | Adobe PDF | View/Open |
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