Synthesis and antitumor evaluation of novel tetrahydrobenzo[4′,5′]thieno[3′,2′:5,6]pyrimido[1,2-b]isoquinoline derivatives

Mahmoud M. ; Abu El-Azm F. ; Ismail M. ; Hekal M. ; Ali Y. ; Hekal, Mohamed 


Abstract


© 2018 Taylor & Francis. In the present study, a novel 8,9,10,11-tetrahydro-7H,14H-benzo[4′,5′] thieno[2′,3′:4,5] -1,3-oxazino[3,2-b]isoquinoline-7,14-dione 5 was prepared by condensation of 2-amino-3-carbethoxy-4,5,6,7-tetrahydrobenzothiophene with homophthalic anhydride under microwave irradiation, followed by alkaline hydrolysis and cyclization using acetyl chloride. Compound 5 was further allowed to react with different nitrogen nucleophiles to get new tetrahydrobenzothienopyrimido isoquinolinone derivatives. The structures of the prepared compounds were elucidated by IR, 1 H-NMR, 13 C-NMR, and mass spectroscopy. The newly prepared compounds were tested in vitro against a panel of two human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2, and mammary gland breast MCF-7. Almost all the tested compounds showed satisfactory activity.


Other data

Issue Date 16-Feb-2018
Journal Synthetic Communications 
URI http://research.asu.edu.eg/123456789/856
DOI 4
http://api.elsevier.com/content/abstract/scopus_id/85040978214
428
48
10.1080/00397911.2017.1406520


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