Efficient MW-Assisted Synthesis of Some New Isoquinolinone Derivatives With In Vitro Antitumor Activity

Hekal, Mohamed ; Abu El-Azm F. 


Abstract


© 2017 Wiley Periodicals, Inc. An efficient and convenient synthesis of novel [1,3]oxazino[3,2-b] isoquinoline-5,12-dione derivative 4 was achieved by the reaction of anthranilic acid with homophthalic anhydride under microwave irradiation, followed by cyclization with acetic anhydride. Some new isoquinolinone and fused isoquinolinone derivatives were prepared via reaction of compound 4 with different nitrogen nucleophiles by using reflux and a focused microwave reactor. Microwave irradiation favored the formation of the desired products with improved yields and shortened reaction times. This is a simple and green method for the synthesis of isoquinolinone derivatives. The structures of the prepared compounds were elucidated by IR, 1 H-NMR, and mass spectroscopy. Some of the newly prepared compounds were tested in vitro against a panel of three human tumor cell lines, namely, hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Almost all of the tested compounds showed satisfactory activity.


Other data

Issue Date 1-Nov-2017
Journal Journal of Heterocyclic Chemistry 
URI http://research.asu.edu.eg/123456789/857
DOI 6
http://api.elsevier.com/content/abstract/scopus_id/85020484626
3056
54
10.1002/jhet.2916


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