Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazole-2(3H)-thione and Azidomethanone Derivatives Based on Quinoline- 4-carbohydrazide Derivatives

Mansoura I. Mohamed,* Nadia G. Kandile, and Howida T. Zaky ; ismail, mansoura 


A new series compounds of quinoline derivatives were synthesized by reaction of 3-(carboxymethyl)-2- arylquinoline-4-carboxylic acids 1a–c with different nucleophiles. The structures of the new compounds were elucidated on the basis of FTIR, 1H-NMR, 13C-NMR spectral data, GC/MS, and chemical analysis. Investigation of antimicrobial activity of all new compounds was evaluated using a broth dilution technique in terms of minimal inhibitory concentration count against four pathogenic bacteria and two pathogenic fungi. Most of the new compounds were significantly active against bacteria and fungi.

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Issue Date Jan-2017

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