Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazole-2(3H)-thione and Azidomethanone Derivatives Based on Quinoline- 4-carbohydrazide Derivatives
Mansoura I. Mohamed,* Nadia G. Kandile, and Howida T. Zaky; ismail, mansoura;
Abstract
A new series compounds of quinoline derivatives were synthesized by reaction of 3-(carboxymethyl)-2-
arylquinoline-4-carboxylic acids 1a–c with different nucleophiles. The structures of the new compounds
were elucidated on the basis of FTIR, 1H-NMR, 13C-NMR spectral data, GC/MS, and chemical analysis. Investigation
of antimicrobial activity of all new compounds was evaluated using a broth dilution technique in
terms of minimal inhibitory concentration count against four pathogenic bacteria and two pathogenic fungi.
Most of the new compounds were significantly active against bacteria and fungi.
arylquinoline-4-carboxylic acids 1a–c with different nucleophiles. The structures of the new compounds
were elucidated on the basis of FTIR, 1H-NMR, 13C-NMR spectral data, GC/MS, and chemical analysis. Investigation
of antimicrobial activity of all new compounds was evaluated using a broth dilution technique in
terms of minimal inhibitory concentration count against four pathogenic bacteria and two pathogenic fungi.
Most of the new compounds were significantly active against bacteria and fungi.
Other data
| Title | Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazole-2(3H)-thione and Azidomethanone Derivatives Based on Quinoline- 4-carbohydrazide Derivatives | Authors | Mansoura I. Mohamed,* Nadia G. Kandile, and Howida T. Zaky ; ismail, mansoura | Issue Date | Jan-2017 |
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