Evaluation of Therapeutic Effect of Rice Husk Silica Combined with Platelets Derived Growth Factor in Hepatic Veno- Occlusive Disease

Abstract

Veno- occlusive disease is an important pattern of hepatotoxicity associated with antineoplastic drugs. The study aimed to investigate the possible therapeutic impact of rice husk silica (RHS) nanoparticles combined with a platelet-derived growth factor (PDGF) on the Veno-occlusive disease in liver (VOD) elicited by dactinomycin (DAC) in rats. Forty-eight male Sprague-Dawely rats were classified into six groups, 8 rats each. The first group served as control, the second, animals were infused by intraperitoneal injection with DAC (0.015 mg/kg; 1-3 days IP). The third group, rats were injected IP with DAC and then at 24 h followed the last dose of DAC received nano RHS incorporated with PDGF twice a week for four weeks. The fourth group, normal animals were injected with RHS. The fifth group normal rats were received with PDGF, and the sixth group normal rats were received nano RHS incorporated with PDGF. The results of this work showed that administration of nano RHS joined with PDGF significantly reversed the oxidative stress effects of DAC that was evidenced by decreasing in liver function. It could be concluded that the nano RHS combined with PDGF is useful in preventing of oxidative stress and hepatic Veno-occlusive induced by receiving chemotherapy (DAC).