Dietary Effect of Coenzyme Q10 on Blood Lipid Levels and Oxidative Stress in Hyperlipidemic Rats

Nora M. El-Sheikh, Mona A. Sadek and Tahany S. Baumy ; Abd el-fattah, Hanaa 


Abstract


The present work was planned to investigate the effect of Coenzyme Q10 (CoQ10) administration as antioxidant on oxidative status as well as the biochemical changes in lipids profile and some liver enzyme activities of healthy and hyperlipidemic rats. Adult male albino rats (n=64) were classified into healthy and hyperlipidemic rats that fed on either balanced or high fat- high cholesterol (HF-HC) diets with and without CoQ10 at the tested dose of 90 mg/kg diet. At the end of the experiment (7 weeks) serum lipids profile, antioxidant status were evaluated and serum enzyme transferases activities were determined. The results of serum lipids profile were significantly decreased (P<0.05) while level of high density lipoprotein-cholesterol (HDL-C) was increased in case of healthy rats fed on HF-HC diet plus CoQ10. The values were decreased by about 6.76%, 11.31%, 9.07%, 9.08% and 20.82% for total lipids (TL), total cholesterol (TC), triacylglycerols (TAG) very low and low density lipoprotein-cholesterol (VLDL-C) and (LDL-C), respectively compared to healthy group fed on HF-HC diet without CoQ10. Serum levels of TL, TC, TAG, VLDL-C and LDL-C were significantly decreased (P<0.05) in case of hyperlipidemic rats maintained on balanced or HF-HC diets supplemented with CoQ10. Also,CoQ10 significantly decrease serum malondialdehyde (MDA) level in case of healthy rats fed on HF-HC diet, and hyperlipidemic rats fed on either balanced or HF-HC diet. While CoQ10 significantly increase erythrocyte superoxide dismutase activity (SOD), hepatic catalase (CAT) and reduced glutathione (GSH) in case of healthy rats fed on HF-HC diet and hyperlipidemic rats fed on balanced or HF-HC diets. CoQ10 caused a significant decrease in serum transferases activity (AST and ALT) in case of healthy rats fed on HF-HC diet, and caused significant decrease in case of hyperlipidemic rats fed on either balanced by about 10.7% (AST) and 26.11% (ALT) or HF-HC diet by about 12.59% (AST) and 7.17 % ( ALT). In conclusion, dietary CoQ10 has a beneficial role in the prevention of the lipids oxidation which reduced the risks of hyperlipidemia and cardiovascular diseases. Key words: coenzyme Q10- oxidative Stress –atherogenic diet- hyperlipidemic animals


Other data

Keywords coenzyme Q10- oxidative Stress –atherogenic diet- hyperlipidemic animals
Issue Date 2010
Publisher Al Azhar Medical Journal, Volume 39(3): 603-616
Journal Al Azhar Medical Journal, Volume 39(3): 603-616 
URI http://research.asu.edu.eg/123456789/952


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