Hematological studies on black cumin oil from the seeds of Nigella sativa L

Enomoto S. ; Asano R. ; Iwahori Y. ; Narui T. ; Okada Y. ; Singab A. ; Okuyama T. 


Abstract


The methanol soluble portion of black cumin oil, which is prepared by compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic acid (AA)-induced platelet aggregation and blood coagulation. By bioactive assay of AA-induced platelet aggregation, the methanol soluble part was purified to isolate a new compound 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol (1) and two known compounds, thymol (2), carvacrol (3), having very strong inhibitory activity. Further, we then examined the isolated compounds (1-3) and eight related compounds by the screening test for AA-induced platelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl group had more potent activity than aspirin, which is well known as a remedy for thrombosis.


Other data

Issue Date 5-Apr-2001
Journal Biological and Pharmaceutical Bulletin 
URI http://research.asu.edu.eg/123456789/980
DOI 3
http://api.elsevier.com/content/abstract/scopus_id/0035080283
307
24
10.1248/bpb.24.307


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