Dokla, Eman

emanelawady@pharma.asu.edu.eg
Department of Pharmaceutical Chemistry - Pharmacy
Interests: Rational design and computational modeling of small molecules targeting cancer‑related pathways, including kinase inhibitors, protein–protein interaction modulators, and epigenetic targets, Design, synthesis, and optimization of small‑molecule anticancer agents, with emphasis on dual‑target inhibitors and molecules modulating mitochondrial respiration and ER‑stress signaling, Development of novel antimicrobial agents and structural optimization toward lead identification and preclinical candidate advancement, Integration of structure‑based and ligand‑based drug design (docking, MD simulations, pharmacophore modeling, and virtual screening) to support discovery of bioactive small molecules across oncology and infectious disease indications,
Internal ID: rp11910
  • 221 Scopus Citations
  • 50 PubMed Citations
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Full Name
Dokla, Eman
 
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Biography
Eman M.E. Dokla is an associate professor at the department of Pharmaceutical Chemistry, Ain Shams University, Egypt. Her current research interest focuses on targeted cancer therapy and the development of novel antimicrobial agents. She has co-authored several peer-reviewed papers on the discovery and development of small-molecule kinase inhibitors targeting breast cancer and acute myeloid leukemia, and protein degraders targeting breast, lung, and oral squamous cell cancers. In this context, her work comprises drug discovery and medicinal chemistry efforts for small-molecule inhibitors’ development and optimization.

Publications

Results 21-23 of 23 (Search time: 0.0 seconds).

Issue DateTitleAuthor(s)
212025A synthetic molecule targeting STAT3 against human oral squamous cell carcinoma cellsLi-Yuan Bai; Po-Chen Chu; Chia-Hsien Feng; Jing-Lan Hu; Liang-Jun Wang; Jing-Ru Weng; Dokla, Eman 
22May-2025Structural Optimization and MD Simulation Study of Benzimidazole Derivatives as Potent Mutant FLT3 Kinase Inhibitors Targeting AMLEl-Deen, Nada Alaa; DeFilippis, RosaAnna; Milik, Sandra N; Patel, Suhana; Ismail, Muhammad I; Khaled, Omar; Ahmed, Tarek Erfan; Abdelfattah, Ayatullah Gamal; Ali, Eslam M H; Gaballah, Maiy Y; McPhillie, Martin J; Abouzid, Khaled A M; Henary, Maged; Minucci, Saverio; Shah, Neil P; Abdel-Aziz, Amal Kamal ; Serya, Rabah ; Dokla, Eman 
31-Dec-2025Tackling microbial resistance with 4H-chromen-4-one derivatives as a novel class of penicillin binding protein 2a inhibitorsShalaby, Menna-Allah W; Abutaleb, Nader S; Elgammal, Yehia; Liang, Hsin-Wen; Abdallah, Inas A; Fishovitz, Jennifer; Seleem, Mohamed N; Abouzid, Khaled A M; Serya, Rabah ; Dokla, Eman