Ain Shams Scholar Collection:

Prediction of fluid responsiveness in mechanically ventilated patients in surgical intensive care unit by pleth variability index and inferior vena cava diameter

2026-05-03T19:55:59Z

Title: Prediction of fluid responsiveness in mechanically ventilated patients in surgical intensive care unit by pleth variability index and inferior vena cava diameter Authors: Elsaidi, Mohamed; Diaaeldin Badr Metwally Kotb Aboelnile; Yasir Ahmed Elbasiony Mohamed Kenawey; Ibrahim Mohammed Alsayed Ahmed Elsherif Abstract: Background Patients may have signs of hypovolemia, but fluid administration is not always beneficial. We are in need of bedside devices and techniques, which can predict fluid responsiveness effectively and safely. This study is aiming to compare the effectiveness and reliability of the pleth variability index (PVI) and IVC distensibility index (dIVC) as predictors of fluid responsiveness by simultaneous recordings in all sedated mechanically ventilated patients in the surgical intensive care unit (ICU). We used the passive leg raising test (PLR) as a harmless reversible technique for fluid challenge, and patients were considered responders if the cardiac index (CI) measured by transthoracic echocardiography (TTE) increased ≥ 15% after passive leg raising test (PLR). Results This observational cross-sectional study was performed randomly on 88 intubated ventilated sedated patients. Compared with CI measured by transthoracic echocardiography, the dIVC provided 79.17% sensitivity and 80% specificity at a threshold value of > 19.42% for fluid responsiveness prediction and was statistically significant ( < .0001), with an area under the curve (AUC) of 0.886 (0.801–0.944), while PVI at a threshold value of > 14% provided 93.75% sensitivity and 87.5% specificity and was statistically significant ( < .0001), with an AUC of 0.969 (0.889–0.988). Conclusion PVI and dIVC are effective non-invasive bedside methods for the assessment of fluid responsiveness in ICU for intubated ventilated sedated patients with sinus rhythm, but PVI has the advantage of being continuous, operator-independent, and more reliable than dIVC.

COVID-19 vaccines research

2026-04-02T13:28:26Z

Title: COVID-19 vaccines research Authors: Adel, Sajad

Clinico-pathological relationship between androgen receptor and tumour infiltrating lymphocytes in triple negative breast cancer

2026-03-30T08:27:11Z

Title: Clinico-pathological relationship between androgen receptor and tumour infiltrating lymphocytes in triple negative breast cancer Authors: Elghazawy, Hagar; Bakkach, Joaira; Helal, Thanaa; Aref, Ahmed M; kelany, mohamed; Abdallah, Lamiaa E; Abdelbakey, Fatma S; Aly, Dalia; Ali, Doaa Z; Ahmed, Mai O; El-Hafeez, Amer Ali Abd; Ghosh, Pradipta; Alorabi, Mohamed Abstract: Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer (BC) with ill-defined therapeutic targets. Androgen receptor (AR) and tumour-infiltrating lymphocytes (TILs) had a prognostic and predictive value in TNBC. The relationship between AR, TILs and clinical behaviour is still not fully understood.

Predictors of poor precautionary practices towards COVID-19 among cancer patients

2026-03-30T08:26:31Z

Title: Predictors of poor precautionary practices towards COVID-19 among cancer patients Authors: Jazieh, Abdul R; Bensalem, Assia A; Bounedjar, Adda; Benbrahim, Zineb; Abusanad, Atlal M; Tashkandi, Emad M; Alnassar, Muath Ama; El Kinge, Abdul Rad; Al-Sukhun, Sana; Alsharm, Abdullah; Errihani, Hassan; Abdelhafiez, Nafisa A; Alkaiyat, Mohammad; Jradi, Hoda; Alorabi, Mohamed Abstract: Objective: Our study goal was to evaluate the behavioral response and practices of cancer patients to the coronavirus disease 2019 (COVID-19) pandemic in the Middle East and north Africa. Methods: A cross-sectional study was conducted using a validated anonymous 45-question survey administered via SurveyMonkey® to cancer patients in 13 centers in Algeria, Egypt, Jordan, Kuwait, Morocco and Saudi Arabia. Results: During the study period (from 21 April to 30 May 2020), 3642 patients participated in the study. The majority of patients (84.81%) were worried about contracting the infection. The reported strict adherence to precautions included avoiding the following actions: hand-shaking (77.40%), hugging and kissing (82.89%), social gathering (90.09%), meeting friends (84.68%) and visiting markets (75.65%). In a multivariate analysis, patients with poor precautionary practices were about twice as likely to cancel their medical appointment or a treatment session. Conclusion: Improving cancer patients' knowledge of and adherence to precautionary measures is needed not just to reduce the risk of acquiring infection but also to minimize the interruption of their medical care.