Serum Anticardiolipin Antibodies In Women With Unexplained Infertility

Abstract

Infertility is customarily defined as the inability to conceive after 1 year of unwanted non-conception with unprotected intercourse in the fertile phase of the menstrual cycle. Unexplained infertility refers to the absence of a definable cause for a couple’s failure to achieve pregnancy after 12 months of attempting conception despite a thorough evaluation. Despite improved diagnostic techniques, the average incidence of unexplained infertility has been reported to be approximately 15%. Antiphospholipid antibodies, in addition to causing pregnancy loss and recurrent miscarriage, may present as biochemical pregnancies or infertility due to the effects on the trophoblast in addition to the effect on clotting. At present, there is insufficient evidence to recommend routine testing for aPL in infertility. However, the identification of B2GPI-dependant antibodies and antibodies in addition to ACA and LA may allow us to identify certain subgroups in the future in whom aPL may be relevant, and in whom effective treatment can be used. However, this diagnosis will also be dependant on the diagnosis of embryonic normality, which is almost impossible to diagnose at present (Carp & Shoenfeld, 2007). The present study was aimed to show the relationship between unexplained infertility and seroprevelance of immunoglobulin G of anticardiolipin antibody.