Nanoduct Sweat Chloride Testing Among Children with Chronic Lung Diseases
Ibtihal Abdel Raouf Mohammed Khadra;
Abstract
T
he terminology of pediatric “chronic lung diseases” include abnormalities in airways, lung parenchyma, blood vessels or pleura. Their causes may result from congenital parenchymal lung defects (such as congenital lobar emphysema, congenital cystic lung, sequestrated lobes…), airway disease (such as bronchiectasis, primary ciliary dyskinesia, cystic fibrosis…) or acquired interstitial lung diseases. Pulmonary exacerbations are a major cause of morbidity and decreased quality of life for patients with chronic lung diseases.
Cystic fibrosis is the most common inherited disorder of childhood. It is caused by abnormalities in the gene that code for the protein called CF transmembrane conductance regulator (CFTR). Lung disease in CF is the major cause of death through a complex process involving impairment of mucociliary clearance, infection, inflammation and structural injury.
Sweat chloride test is a test that measures the level of chloride in sweat, due to defective chloride channels (CFTR), the concentration of chloride in sweat is elevated in individuals with CF. Although genetic tests have become important methods for diagnosing cystic fibrosis in children, the sweat chloride test is still the standard.
In this cross sectional observational study, we measured sweat chloride test levels among children with chronic lung diseases using Nanoduct neonatal sweat analysis system.
The present study included forty (40) patients with chronic lung diseases who were referred to the pediatric chest clinic, children's hospital, Ain Shams University They were subdivided into two group ILD group: It included twenty (20) patients with interstitial lung disease and Bronchiectasis group: It include twenty (20) patients with bronchiectasis.
The age of patients included in the study (n=40) ranged between 1.3-13 years with mean age 7.77±3.57 years in ILD group and 1.3-14 years with mean age 7.13±4.27 years in bronchiectasis group. Among them sixty seven were females (67%) and thirty three were males (33%).
he terminology of pediatric “chronic lung diseases” include abnormalities in airways, lung parenchyma, blood vessels or pleura. Their causes may result from congenital parenchymal lung defects (such as congenital lobar emphysema, congenital cystic lung, sequestrated lobes…), airway disease (such as bronchiectasis, primary ciliary dyskinesia, cystic fibrosis…) or acquired interstitial lung diseases. Pulmonary exacerbations are a major cause of morbidity and decreased quality of life for patients with chronic lung diseases.
Cystic fibrosis is the most common inherited disorder of childhood. It is caused by abnormalities in the gene that code for the protein called CF transmembrane conductance regulator (CFTR). Lung disease in CF is the major cause of death through a complex process involving impairment of mucociliary clearance, infection, inflammation and structural injury.
Sweat chloride test is a test that measures the level of chloride in sweat, due to defective chloride channels (CFTR), the concentration of chloride in sweat is elevated in individuals with CF. Although genetic tests have become important methods for diagnosing cystic fibrosis in children, the sweat chloride test is still the standard.
In this cross sectional observational study, we measured sweat chloride test levels among children with chronic lung diseases using Nanoduct neonatal sweat analysis system.
The present study included forty (40) patients with chronic lung diseases who were referred to the pediatric chest clinic, children's hospital, Ain Shams University They were subdivided into two group ILD group: It included twenty (20) patients with interstitial lung disease and Bronchiectasis group: It include twenty (20) patients with bronchiectasis.
The age of patients included in the study (n=40) ranged between 1.3-13 years with mean age 7.77±3.57 years in ILD group and 1.3-14 years with mean age 7.13±4.27 years in bronchiectasis group. Among them sixty seven were females (67%) and thirty three were males (33%).
Other data
| Title | Nanoduct Sweat Chloride Testing Among Children with Chronic Lung Diseases | Other Titles | اختبار كلوريد العرق بين الأطفال الذين يعانون من أمراض الرئة المزمنة باستخدام جهاز النانو | Authors | Ibtihal Abdel Raouf Mohammed Khadra | Issue Date | 2014 |
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