Role of Allergy Induced by Milk and its ProductsIn Some Autoimmune Diseases

Abstract

There are several reports on the prevalence and importance of milk allergens in the induction of allergic diseases, whereas its role in the induction of autoimmune disease was rarely studied. So, the present work aimed to study the diagnosis and the efficacy of oral antigen specific immunotherapy (OAIT) on two groups of autoimmune disease patients namely, rheumatoid arthritis (RA), group II, and systemic lupus erythematosus (SLE), group III, who have allergens for milk to clarify and provide an effective treatment option by using milk elimination and milk immunotherapy as a new type of treatment for some autoimmune disease in Egypt. From the assessment of the data obtained and the clinical outcome of RA and SLE patients after food elimination strategy and milk immunotherapy, Results: The data obtained in comparing immunotherapy treatment using milk antigen and elimination, it was evident that there were significant reductions ( p< 0.001) in the levels of total IgE, specific IgE, Rheumatoid factor (RF), C-reactive protein (CRP), Anti nuclear antibodies (ANA) and anti-double stranded-DNA antibodies (Antids-DNA) compared topretreated levels.

Moreover, the immunotherapy induced “blocking antibodies” by phagocytic inhibition test (PIT %). Complement component 3(C3), and Complement component 4 (C4) levels. More improvement was noticed in systemic lupus erythematosus patients as a result of the immunotherapy.

Conclusion: milk desensitization is a valuable addition to our country for the treatment of autoimmune conditions. It is exceptionally safe, offers convenience for the patient, and provides effective treatment for rheumatoid arithritis and systemic lupus erythematosus patients which reduce the severity of disease and improve the immune cells and function in controlling the disease. Key words: Immunotherapy;Milk Allergy; Autoimmun Disease