EFFECT OF AN AROMATASE ENZYME INHIBITOR (FADROZOLE) ON FERTILITY OF SOME LABORATORY ANIMALS
RAFEA ATTIYA MUTKHATRI EL-SAADI;
Abstract
The aim of the present study was to evaluate the effects of the administration of a potent non-steroidal aromatase inhibitor, Fadrozole, on reproductive function of mice. The following items were investigated:-
1- The effects of administration of Fadrozole, on reproductive organs of immature mice in both male and female mice (sex organs weight, histological examination and hormonal assay)
2- The effects of administration of Fadrozole on sexual and aggressive behavior and fertility of adult mature male mice. Its effects on female reproductive organs, fertility, pregnancy and resultant feti were also investigated.
3- The effects of inhalation of air polluted with diesel exhaust during pregnancy
(histological features, hormonal assay and effect on feti were studied).
Four experiments were carried out:- The first experiment:
The aim of this experiment was to evaluate the effect of Fadrozole injection on reproductive functions of immature mice.
Twenty immature mice of both sexes (21 days old) were allocated into 4 groups each of 5 mice. Two control groups (male and female) were injected s/c daily with 0.1 ml saline per mouse for 35 days. The two treated groups were injected s/c daily with 25J.lg Fadrozole per mouse for 35 days. At day 36 the body weight and sex organ weights of all animals (control and treated) was recoded. Blood samples were collected, estradiol brain levels and plasma hormones (testosterone, estradiol and progesterone) were estimated. Results showed that injection of Fadrozole in male mice significantly increased plasma testosterone, improved testicular spermatogenic function, lowered brain and plasma estradiol levels. In females, brain and plasma estradiol levels were decreased. In the control group, it was found that male brain tissue has higher estradiol levels than that of females.
1- The effects of administration of Fadrozole, on reproductive organs of immature mice in both male and female mice (sex organs weight, histological examination and hormonal assay)
2- The effects of administration of Fadrozole on sexual and aggressive behavior and fertility of adult mature male mice. Its effects on female reproductive organs, fertility, pregnancy and resultant feti were also investigated.
3- The effects of inhalation of air polluted with diesel exhaust during pregnancy
(histological features, hormonal assay and effect on feti were studied).
Four experiments were carried out:- The first experiment:
The aim of this experiment was to evaluate the effect of Fadrozole injection on reproductive functions of immature mice.
Twenty immature mice of both sexes (21 days old) were allocated into 4 groups each of 5 mice. Two control groups (male and female) were injected s/c daily with 0.1 ml saline per mouse for 35 days. The two treated groups were injected s/c daily with 25J.lg Fadrozole per mouse for 35 days. At day 36 the body weight and sex organ weights of all animals (control and treated) was recoded. Blood samples were collected, estradiol brain levels and plasma hormones (testosterone, estradiol and progesterone) were estimated. Results showed that injection of Fadrozole in male mice significantly increased plasma testosterone, improved testicular spermatogenic function, lowered brain and plasma estradiol levels. In females, brain and plasma estradiol levels were decreased. In the control group, it was found that male brain tissue has higher estradiol levels than that of females.
Other data
| Title | EFFECT OF AN AROMATASE ENZYME INHIBITOR (FADROZOLE) ON FERTILITY OF SOME LABORATORY ANIMALS | Other Titles | تأثير مثبط انزيم الأرماتيز( فادرزول ) على خصوبة بعض حيوانات التجارب | Authors | RAFEA ATTIYA MUTKHATRI EL-SAADI | Issue Date | 2010 |
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