Synthesis and Characterization of Some Ternary Complexes and their applications

Abstract

Ternary complexes of Cu(II) and Zn(II) with the amino acid, glycine (gly), as a primary ligand, and hydroxy acids i.e. salicylic acid (HL1), lactic acid (HL2) and glycolic acid (HL), as a secondary ligand where prepared in a slightly acidic medium and isolated in a ratio (1:1:1). The ternary complexes are synthesized and characterized using elemental analysis, spectral (UV-vis, IR) studies, thermal techniques, magnetic measurements, ESR and their biological activity were investigated. A square planar geometry for Cu (II) and Zn (II) is proposed. In order to evaluate the biological activity of hydroxy acids and to assess the role of metal ion on biological activity, the hydroxy acids and their metal complexes have been studied in vitro antibacterial against Staphylococcus Aureus, Escherichia Coli, and Pseudomonas Aeruginosa. In most cases, a higher activity was exhibited upon coordination with metal ions. Cu (II) and Zn (II) ternary complexes prepared were then incorporated into Solid lipid nanoparticles (SLN). SLN are the new generation of nanoparticulate active substance vehicles and are attracting major attention as novel colloidal drug carriers for topical use.