Prevention of Contrast Induced Nephropathy by Ischemic Preconditioning in Patients Undergoing Percutaneous Coronary Angiography

Abstract

Contrast-induced nephropathy (CIN) is the acute deterioration of renal function after parenteral administration of radio contrast media in the absence of other causes. The true incidence of CIN is difficult to assess because of differences among the various published studies in the definition of CIN, the proportion of high-risk patients, the types of contrast media, and the use of preventive measures. In this study, 100 patients undergoing PCI with base line creatinine clearance < 60mg/dl were studied. Patients were divided into 2 groups (ischemic preconditioning group and control group), 50 patients in each group. The incidence of CIN was markedly lower in ischemic preconditioning group 14% VS 38% in control group. The difference of incidence of CIN between both groups was found to be (24%). The amount of dye used., decreased LVEF as well as the presence of significant LAD lesion were significant risk factors for occurrence of CIN.