Sclerostin Levels in Childhood and Adolescent in type 1 DM: Correlation to Bone Disease

Abstract

T ype 1 diabetes mellitus is caused by deficiency of insulin secretion due to pancreatic β-cell damage. It is the most common endocrine-metabolic disorder of childhood and adolescence, with important consequences for physical and emotional development. Along with increased risk of complications including retinopathy, nephropathy, neuropathy, and cardiovascular events. Adults with type 1 diabetes have decreased Bone Mineral Density (BMD) compared with control subjects. In fact, osteoporosis is the most significant metabolic bone disease in individuals with diabetes and may have risk of complications, including hip fracture. Diabetes complications represent a huge burden for patient and health services. The fight against each single complication has led to significant improvement in diabetes care, especially for micro-vascular complications, yet, they remain a major source of morbidity and mortality. Acommon approach for the prevention and treatment of diabetes complications relies on the understandingthe natural history of bone mineral density changes in young adults with type1 diabetes may elucidate how the disease progresses, provide opportunities for prevention of significant bone loss, and presumably fracture.