ADVERSE EFFECTS OF SOME FOOD INTERACTIONS ON EXPERIMENTAL ANIMALS

Abstract

Food-food, food-herb and herb-herb interactions are considered serious problems, which greatly affected human health. However, many studies were interested of drug-drug, drug-herb and drug-food interactions. Several patients treated with monoamine oxidase inhibitors as antidepressant drugs were suffered from hypertensive crisis, acute heart failure, brain hemorrhage, and may be sudden death after they had eaten food containing biogenic amines. With observation that natural MAO reversible inhibitors were found in a number of foods and herbs such as curcumin in turmeric, piperine in black pepper, berberine, quercetin, resveratrol, anthocyanins, coumarin derivatives and ginkgo biloba. Therefore, the present study was performed to determine the adverse effects of interaction between food containing biogenic amines and food or herb containing monoamine oxidase inhibitors. To achieve this aim, Thirty five male Albino rats weighing about 100g were purchased, divided into 5 groups and treated with the following treatments by an oral administration every other day for 60 days: Group (1): Fed on a normal diet and served as a control. Group (2): Fed on Tyramine (20 mg/kg) + Curcumin (40 mg/kg). Group (3): Fed on Tyramine (20 mg/kg) + Piperine (30 mg/kg). Group (4): Fed on Dopamine (20 mg/kg) + Curcumin (40 mg/kg). Group (5): Fed on Dopamine (20 mg/kg) + Piperine (30 mg/kg). The adverse effects occurring for experimental rats with oral administration of both biogenic amines (e.g. tyramine or dopamine) + MAO inhibitors (e.g. curcumin or piperine) were investigated through determination of blood pressure measurements, hematological analyses and different blood biochemical assays (e.g. AST, ALT, CPK, LDH enzymes, glucose, albumin, triglycerides, cholesterol, creatinine, uric acid & urea).