Metabolomic Response of Feeding Functional Foods and Exercise on Obesity Risk in Rats

Abstract

Obesity is a significant contributor to the global burden of the most serious chronic diseases and becomes the fifth leading risk factors for deaths with more than 1.9 billion adults worldwide are overweight and 600 million are obese. Therefore and based on the accelerating increases in obesity incidence and the risk factors for the global chronic diseases, efficient novel technology for disease management such as metabolomics is necessary. Complementing this topic, developing functional foods or nutraceutical compounds for obesity management may be more acceptable strategy for dealing with the majority of the population that is currently suffering from overweight or obesity in the world. It is expected that, both nutraceutical compounds and exercises play the potential roles in obesity management. Some functional foods such as Pomegranate (Punicagranatum L., Punicaceae), grapefruit (Citrus paradise, Macfad.), and Red cabbage (Brassica oleracea L; Fam, Brassicaseae) are used in this study because they are enrich in polyphenols (i.e. tannins and anthocyanins), isocitric acid, flavonoids, coumarins, and hydroxyl cinnamates, anthocyanins and sulphur compounds, respectively, in addition to natural antioxidants. These nutraceutical compounds needs advanced technology to assess their therapeutic efficiency and safety margin.