Use of antisense in vitro for inhibition of hepatitis C virus replication •
Ahmed Mohamed Fahmy;
Abstract
Hepatitis C virus (HCV) infection is a global blood borne disease that affects almost 3% of the world's population with a morbidity and mortality that are second only to HIV among the emerging infections. About 27% of cases of cirrhosis and 25% of instances of hepatocellular carcinoma arise in HCV infected people.
The highest estimated prevalence of HCV has been described in Egypt,
6-28% with an average of approximately 13.8% of the population are chronically infected.
Hepatitis C virus (HCV) is a small enveloped positive stranded RNA
virus that belongs to the Hepacivirus genus in the Flaviviridae family.It contains a genome of about 9,5Kb that encode a polyprotein precursor of about 3000 amino acid residues .The HCV genome shows remarkable sequence variation and globally,HCV is distributed with at least 6 different genotypes,furthermore, complicated quasispecies and frequent mutations of viral genomes have also emerged.
The viral polyprotein precursor is cleaved by the host and viral proteases to generate 10 proteins .These viral proteins not only function in viral replication but also affect a variety of cellular functions. Although several mechanisms have been proposed, the mechanisms of HCV infection and replication in targeted cells and the pathogenesis of hepatic diseases are all poorly understood.
The currently available therapy of peginterferon (PEG-IFN) combined with ribavirin (RBV) for suitable patients with chronic hepatitis C virus (HCV) infection can eradicate virus permanently in those patients who achieve a sustained virologic response (SVR). However, this treatment is
The highest estimated prevalence of HCV has been described in Egypt,
6-28% with an average of approximately 13.8% of the population are chronically infected.
Hepatitis C virus (HCV) is a small enveloped positive stranded RNA
virus that belongs to the Hepacivirus genus in the Flaviviridae family.It contains a genome of about 9,5Kb that encode a polyprotein precursor of about 3000 amino acid residues .The HCV genome shows remarkable sequence variation and globally,HCV is distributed with at least 6 different genotypes,furthermore, complicated quasispecies and frequent mutations of viral genomes have also emerged.
The viral polyprotein precursor is cleaved by the host and viral proteases to generate 10 proteins .These viral proteins not only function in viral replication but also affect a variety of cellular functions. Although several mechanisms have been proposed, the mechanisms of HCV infection and replication in targeted cells and the pathogenesis of hepatic diseases are all poorly understood.
The currently available therapy of peginterferon (PEG-IFN) combined with ribavirin (RBV) for suitable patients with chronic hepatitis C virus (HCV) infection can eradicate virus permanently in those patients who achieve a sustained virologic response (SVR). However, this treatment is
Other data
| Title | Use of antisense in vitro for inhibition of hepatitis C virus replication • | Other Titles | استخدام الشفرة العكسية لتثبيط تكاثر الفيروس الكبدى سى معمليا | Authors | Ahmed Mohamed Fahmy | Issue Date | 2009 |
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