Effect Of The Herbal Extract AsafoetidaOn An Experimental Animal Model Of Allergic Bronchial Asthma
Sylvia Wefky Abo El-Fadle;
Abstract
Asthma is a chronic inflammatory disorder of the airwaysthat induces a range of subclinical and clinical effectsthat arenot only limited to hyperresponsiveness but also airflow limitation, and respiratory symptoms(Motta and van Oosterhout, 2006).
Complex genetic and environmentalfactors are at the origin of asthma, but the current viewattributes the main effector role to T-lymphocytes(Motta and van Oosterhout, 2006).T-helper 2 (Th2) cells are now considered the mainactor in the onset and development of allergic asthma.Irrespective of an absolute requirement for IgE antibody, the development of Th2-type lymphocyte immune responses )characterized by IL-4, IL-5, IL-10 and IL-13 cytokine expression) favors allergic sensitization of the respiratory tract(Kimber and Dearman, 2005).
Triggers of asthma exacerbation include viral infections, certain animal allergens and criteria air pollutants, mites, environmentaltobacco smoke, mold, chemical irritants, and exercise in cold air(Myatt et al., 2008).
Despite the recent advances in understanding of the pathophysiology and targets for therapeutic interventions in asthma, the use of inhaled corticosteroids is still the cornerstone of treatment in chronic asthma. But some patients will still require additionaltherapy.Currently, some novel therapeutic agents acting on specific componentsof the inflammatory pathways in asthma are emerging(Bello and Njoku, 2007).Also,conventional medications such as bronchodilators, inhaled or oral steroids and conventional drug therapies have many side effects(Shenfield et al., 2002).
Herbal preparations have beencited as the third most popular complementarytreatment modality by Britishasthma sufferers. Thehistorical importance of herbal medicine in the treatment of asthma is unquestionable.Four of the five classes of drugs currently used to treat asthma namely ß2 agonists, anticholinergics,methyl-xanthines and cromoneshave origins in herbal treatments going back to atleast 5000 years(Huntley and Ernst, 2000).
Experimental animal models of allergic asthma allow researchers to identify novel mechanisms of disease, and test the ability of therapeutic interventions to limit the severity or induction of allergic asthmatic inflammation(Barrett et al., 2003)
Complex genetic and environmentalfactors are at the origin of asthma, but the current viewattributes the main effector role to T-lymphocytes(Motta and van Oosterhout, 2006).T-helper 2 (Th2) cells are now considered the mainactor in the onset and development of allergic asthma.Irrespective of an absolute requirement for IgE antibody, the development of Th2-type lymphocyte immune responses )characterized by IL-4, IL-5, IL-10 and IL-13 cytokine expression) favors allergic sensitization of the respiratory tract(Kimber and Dearman, 2005).
Triggers of asthma exacerbation include viral infections, certain animal allergens and criteria air pollutants, mites, environmentaltobacco smoke, mold, chemical irritants, and exercise in cold air(Myatt et al., 2008).
Despite the recent advances in understanding of the pathophysiology and targets for therapeutic interventions in asthma, the use of inhaled corticosteroids is still the cornerstone of treatment in chronic asthma. But some patients will still require additionaltherapy.Currently, some novel therapeutic agents acting on specific componentsof the inflammatory pathways in asthma are emerging(Bello and Njoku, 2007).Also,conventional medications such as bronchodilators, inhaled or oral steroids and conventional drug therapies have many side effects(Shenfield et al., 2002).
Herbal preparations have beencited as the third most popular complementarytreatment modality by Britishasthma sufferers. Thehistorical importance of herbal medicine in the treatment of asthma is unquestionable.Four of the five classes of drugs currently used to treat asthma namely ß2 agonists, anticholinergics,methyl-xanthines and cromoneshave origins in herbal treatments going back to atleast 5000 years(Huntley and Ernst, 2000).
Experimental animal models of allergic asthma allow researchers to identify novel mechanisms of disease, and test the ability of therapeutic interventions to limit the severity or induction of allergic asthmatic inflammation(Barrett et al., 2003)
Other data
| Title | Effect Of The Herbal Extract AsafoetidaOn An Experimental Animal Model Of Allergic Bronchial Asthma | Other Titles | تاثيرالمستخلص العشبي الاسافيتدا علي نموذج حيواني تجريبي مصاب بربو شعبي | Authors | Sylvia Wefky Abo El-Fadle | Issue Date | 2015 |
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