MiRNA-Based Gene Therapy for Hepatocellular Carcinoma
Bangly Saeed Saleh Soliman;
Abstract
Bangly Soliman1, 2* 1Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt. 2Informatics and Systems Department, Biomedical Informatics and Chemo-Informatics Group, Centre of Excellence for Advanced Sciences (CEAS), Division of Engineering Research, National Research Centre, Cairo, Egypt.
Interest in micro-RNAs is sparking as more insights into their roles as master regulators of cellular processes emerge. Micro-RNAs possess tumor suppressor activity that makes them potential new anti-cancer agents for different tumors including hepatocellular carcinoma.
The current study aimed to evaluate three putative tumor suppressor miRNAs (let-7a, miR-34a, and miR-199a/b) that act against HCC development and progression. In silico analysis using recent and novel servers (miRror Suite, DAVID, miRGator v3.0, GeneTrail and miRWalk) was performed to demonstrate the combinatorial and the individual regulation of the three miRNAs on the expression of specific target genes from liver cancer-specific expression data sets. The analysis focused mainly on the target oncogenes involved in HCC/cancer hallmarks and various activities of the immune system.
Interest in micro-RNAs is sparking as more insights into their roles as master regulators of cellular processes emerge. Micro-RNAs possess tumor suppressor activity that makes them potential new anti-cancer agents for different tumors including hepatocellular carcinoma.
The current study aimed to evaluate three putative tumor suppressor miRNAs (let-7a, miR-34a, and miR-199a/b) that act against HCC development and progression. In silico analysis using recent and novel servers (miRror Suite, DAVID, miRGator v3.0, GeneTrail and miRWalk) was performed to demonstrate the combinatorial and the individual regulation of the three miRNAs on the expression of specific target genes from liver cancer-specific expression data sets. The analysis focused mainly on the target oncogenes involved in HCC/cancer hallmarks and various activities of the immune system.
Other data
| Title | MiRNA-Based Gene Therapy for Hepatocellular Carcinoma | Other Titles | "علاج جيني للسرطان الكبدي باستخدام الميكرو- رنا" | Authors | Bangly Saeed Saleh Soliman | Issue Date | 2017 |
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