Effect of Bone Marrow-derived Mesenchymal Stem Cells Transplantation on Vascular Functions in Experimental Diabetic Nephropathy
Einas Mohamed Nagib;
Abstract
SUMMARY AND CONCLUSION
T
he present study was planned in order to assess the vascular changes in experimental diabetic nephropathy and the effect of treatment with the bone marrow-derived mesenchymal stem cells on the observed changes.
This work was performed on 62 adult female Albino rats, divided into 3 groups:
1. Control group (N=20): Rats in this group received i.p. injection of STZ solvent (1 ml citrate buffer), then studied after 8 weeks.
2. Untreated diabetic nephropathy (u-DN) group (N=20):Rats in this group were injected by a single dose of STZ at a dose of 35 mg/kg to induce diabetic nephropathy, then studied after 8 weeks..
3. MSCs treated diabetic nephropathy (t-DN) group (N= 22): Rats in this group were injected by a single dose of STZ at a dose of 35 mg/kg to induce diabetic nephropathy then 4 weeks later the rats were treated with rats bone marrow-derived MSCs transplantation, then sacrificed 4 weeks post treatment.
T
he present study was planned in order to assess the vascular changes in experimental diabetic nephropathy and the effect of treatment with the bone marrow-derived mesenchymal stem cells on the observed changes.
This work was performed on 62 adult female Albino rats, divided into 3 groups:
1. Control group (N=20): Rats in this group received i.p. injection of STZ solvent (1 ml citrate buffer), then studied after 8 weeks.
2. Untreated diabetic nephropathy (u-DN) group (N=20):Rats in this group were injected by a single dose of STZ at a dose of 35 mg/kg to induce diabetic nephropathy, then studied after 8 weeks..
3. MSCs treated diabetic nephropathy (t-DN) group (N= 22): Rats in this group were injected by a single dose of STZ at a dose of 35 mg/kg to induce diabetic nephropathy then 4 weeks later the rats were treated with rats bone marrow-derived MSCs transplantation, then sacrificed 4 weeks post treatment.
Other data
| Title | Effect of Bone Marrow-derived Mesenchymal Stem Cells Transplantation on Vascular Functions in Experimental Diabetic Nephropathy | Other Titles | 2017 تأثير زراعة الخلايا الجذعية الوسيطة المستمدة من نخاع العظام على وظائف الأوعية الدموية في الاعتلال الكلوي الناتج عن مرض البول السكري التجريبي | Authors | Einas Mohamed Nagib | Issue Date | 2017 |
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