VINORELBINE AND CISPLATIN IN VISCERAL METASTATIC \ BREAST CANCER PREVIOUSLY RECEIVED ANTHACYCLINE
Wesam Ali El sherif;
Abstract
•Chemotherapy plays a central role in the treatment of visceral metastatic breast cancer. The aim of this work is assess the response rate and the toxicity of vinorelbine and cisplatin in visceral
;metastatic breast cancer previously received anthracycline .a total of24 patients were included
"in this controlled trial carried out at NEMROK . Eligibility criteria includes age up to 70
:performance status score 0-2 histolgicaly .proved breast •cancer with evidence of visceral metastasis, patients received the following chemotherapy protocol: navelbine 25 mglm2 in day
':J&8, cisplatin 80 mglm2 day I, cycle repeated evei)' 3 weeks .the over all response rate is 31 %
"7/22 patients, the main toxicity in this study is neutropenia and neutropenic fever, 2 deaths occurred due to septic shock, grade iii-iv neutropenia occurred in 22.2% of cycles .from the study we can conclude that navelbine•cisplatin is a reasonable combination in metastatic breast cancer, however more prospective randomized trials are needed to consolidate this .finding is needed.
;metastatic breast cancer previously received anthracycline .a total of24 patients were included
"in this controlled trial carried out at NEMROK . Eligibility criteria includes age up to 70
:performance status score 0-2 histolgicaly .proved breast •cancer with evidence of visceral metastasis, patients received the following chemotherapy protocol: navelbine 25 mglm2 in day
':J&8, cisplatin 80 mglm2 day I, cycle repeated evei)' 3 weeks .the over all response rate is 31 %
"7/22 patients, the main toxicity in this study is neutropenia and neutropenic fever, 2 deaths occurred due to septic shock, grade iii-iv neutropenia occurred in 22.2% of cycles .from the study we can conclude that navelbine•cisplatin is a reasonable combination in metastatic breast cancer, however more prospective randomized trials are needed to consolidate this .finding is needed.
Other data
| Title | VINORELBINE AND CISPLATIN IN VISCERAL METASTATIC \ BREAST CANCER PREVIOUSLY RECEIVED ANTHACYCLINE | Other Titles | الفينورلبين والسيسبلاتين لعلاج اورام الثدى المنتشرة للاحشاء والتى تلقت علاج بواسطة الانثراسيلكلين | Authors | Wesam Ali El sherif | Issue Date | 2001 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| وسام على الشريف.pdf | 306.62 kB | Adobe PDF | View/Open |
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