Evaluation of Transient Elastography as a Noninvasive Method for Diagnosis and Detection of Degree of Liver Fibrosis in Chronic Hepatitis C Patients in Comparison with Liver Biopsy
Ahmed Abbas Abdo Ahmed;
Abstract
SUMMARY
H
epatitis C is a liver disease caused by the hepatitis C virus: the virus can cause both acute and chronic hepatitis infection, ranging in severity from a mild illness lasting a few weeks to a serious, lifelong illness. Hepatitis C is found worldwide. The most affected regions are Central and East Asia and North Africa. The hepatitis C epidemic can be concentrated in certain high-risk populations (for example, among people who inject drugs); and/or in general populations. There are multiple strains (or genotypes) of the HCV virus and their distribution varies by region.
After a person has been diagnosed with chronic hepatitis C infection, they should have an assessment of the degree of liver damage (fibrosis and cirrhosis). This can be done by liver biopsy or through a variety of non-invasive tests. One of the best tests that assess the degree of liver fibrosis is transient elastography (fibroscan). Liver stiffness measurement by fibroscan is performed on the same way as the LB examination. we can use the Fibroscan scoring card to convert Fibroscan results measured in (kPa) into the Metavir scale F1-F4.
The aim of this study is to evaluate transient elastography as a non- invasive method for diagnosis and detection of degree of liver fibrosis in chronic hepatitis C patients in comparison with liver biopsy.
This study was done in the period between september 2013 to November 2014. It included 30 Egyptian patients who were HCV +ve. They were recruited from Internal Medicine and Hepatology outpatient clinics and inpatient wards at Ain Shams University Hospitals. All patients enrolled in the study were subjected to detailed history taking, full physical examination, laboratory investigations, imaging studies which included pelvi-abdominal ultrasonography, liver biopsy and transient elastography.
All data were statistically analyzed. Results were compared to results of similar researches; where this study found that the fibroscan has high Sensitivity (81.8%) and Specificity (84.2%) in comparison to liver biopsy.
H
epatitis C is a liver disease caused by the hepatitis C virus: the virus can cause both acute and chronic hepatitis infection, ranging in severity from a mild illness lasting a few weeks to a serious, lifelong illness. Hepatitis C is found worldwide. The most affected regions are Central and East Asia and North Africa. The hepatitis C epidemic can be concentrated in certain high-risk populations (for example, among people who inject drugs); and/or in general populations. There are multiple strains (or genotypes) of the HCV virus and their distribution varies by region.
After a person has been diagnosed with chronic hepatitis C infection, they should have an assessment of the degree of liver damage (fibrosis and cirrhosis). This can be done by liver biopsy or through a variety of non-invasive tests. One of the best tests that assess the degree of liver fibrosis is transient elastography (fibroscan). Liver stiffness measurement by fibroscan is performed on the same way as the LB examination. we can use the Fibroscan scoring card to convert Fibroscan results measured in (kPa) into the Metavir scale F1-F4.
The aim of this study is to evaluate transient elastography as a non- invasive method for diagnosis and detection of degree of liver fibrosis in chronic hepatitis C patients in comparison with liver biopsy.
This study was done in the period between september 2013 to November 2014. It included 30 Egyptian patients who were HCV +ve. They were recruited from Internal Medicine and Hepatology outpatient clinics and inpatient wards at Ain Shams University Hospitals. All patients enrolled in the study were subjected to detailed history taking, full physical examination, laboratory investigations, imaging studies which included pelvi-abdominal ultrasonography, liver biopsy and transient elastography.
All data were statistically analyzed. Results were compared to results of similar researches; where this study found that the fibroscan has high Sensitivity (81.8%) and Specificity (84.2%) in comparison to liver biopsy.
Other data
| Title | Evaluation of Transient Elastography as a Noninvasive Method for Diagnosis and Detection of Degree of Liver Fibrosis in Chronic Hepatitis C Patients in Comparison with Liver Biopsy | Other Titles | تقييم الفيبروسكان باعتباره طريقة غير تداخلية لتشخيص وتحديد درجة تليف الكبد في المرضى الذين يعانون التهاب الكبد الوبائي المزمن سى مقارنة مع عينة الكبد | Authors | Ahmed Abbas Abdo Ahmed | Issue Date | 2015 |
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