SERUM LEVEL OF IL 22 IN PSORIATIC PATIENTS AND ITS RELATION TO DISEASE SEVERITY

Abstract

Psoriasis is a common autoimmune disease that occurs worldwide. Dysregulation of the immune system results in abnormal proliferation and differentiation of keratinocytes. Pro-inflammatory, T helper-1(Th1) cytokines and chemokines such as tumor necrotic factor-α (TNF-α) and interferon-γ (IFN-γ) are key cytokines in development of psoriatic skin lesions. Interleukin-22 (IL-22) has been shown to play an important role in psoriasis. IL-22, a member of the interleukin-10 (IL-10) family, is a major cytokine involved in the distinctive epidermal alteration and production of antimicrobial peptides in psoriatic skin lesions. Interleukin-22 is a downstream effector molecule produced by various cell types such as Th1, Th-17, natural killer-T cells (NKT), dendritic cells and the identified distinctive Th-22 subset, this means that most of the psoriatic T cells produce IL-22, this means that most of the psoriatic T cells produce IL-22. In the present study‚ our main objective was to evaluate serum level of IL-22 in patients with psoriasis vulgaris in relation to age and sex matched healthy controls