Clinical Evaluation of the Analgesic Effect of Magnesium Sulfate Infusion in the Perioperative Period
Yasser Mohamed Rida;
Abstract
Recent researches have shown that NMDA receptor antagonists inlllbit win-up the frequency dependent increase in firing of dorsal hom neurons following c-fibers stimulation.
Accordingly these agents can prevent the induction of central sensitization due to peripheral nociceptive stimulation and can abolish hypersensitivity once it is established.
NMDA receptor channel complex contains binding sites for non competitive antagonists one of these is magnesium which block the NMDA channel produces a dramatic reduction of the NMDA induced currents, decreased the extra cellular magnesium increase the effect of NMDA agonists is enhanced.
It is suggested that NMDA antagonists may play a role in post operative analgesia, owing to the fact that major surgery is usually followed by a significant reduction in serum magnesium concentrations
Prevention of hypomagnesaemia, intra & postoperatively may be of importance for post operative analgesia.
Magnesium may exert its antinociceptive effect via blockade of NMDA receptor complex or non-specific effect via prevention of hypomagnesaemia.
Accordingly these agents can prevent the induction of central sensitization due to peripheral nociceptive stimulation and can abolish hypersensitivity once it is established.
NMDA receptor channel complex contains binding sites for non competitive antagonists one of these is magnesium which block the NMDA channel produces a dramatic reduction of the NMDA induced currents, decreased the extra cellular magnesium increase the effect of NMDA agonists is enhanced.
It is suggested that NMDA antagonists may play a role in post operative analgesia, owing to the fact that major surgery is usually followed by a significant reduction in serum magnesium concentrations
Prevention of hypomagnesaemia, intra & postoperatively may be of importance for post operative analgesia.
Magnesium may exert its antinociceptive effect via blockade of NMDA receptor complex or non-specific effect via prevention of hypomagnesaemia.
Other data
| Title | Clinical Evaluation of the Analgesic Effect of Magnesium Sulfate Infusion in the Perioperative Period | Other Titles | التقييم الالكلينيكي لتأثير سلفات الماغنسيوم كمسمن بالري الوريدي في فترة العمليات | Authors | Yasser Mohamed Rida | Issue Date | 2000 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| Yasser Mohamed Rida.pdf | 2.21 MB | Adobe PDF | View/Open |
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