Intravenous Lipids Administration Effect on Macrophages Phagocytic Function in Neonatal Infection

Abstract

The use of intravenous lipids emulsion during sepsis is the subject of controversy because it may interfere with phagocytosis of microbes by macrophages and may lead to significant hypertriglyceridemia (Shouman et al., 2012). Our study aimed to compare rate of bacterial clearance and outcome in neonates using lipids in total parental nutrition. This study was conducted on 40 preterm neonatesdivided into two groups, 20preterm neonates who met the criteria for blood stream infection and received the usual dose of IV lipids according to the unit’s standard protocol and 20 preterm neonates who met the criteria for blood stream infection and did not receive TPN. For all neonates included in the study the following were performed: - Phagocytic function of macrophages and triglyceride level. The results of our study were - Phagocytic Function is not impaired in neonates who received TPN. - Phacocytic function is affected by triglyceride level and birth weight. - Triglyceride level is not increased in cases group. - Platelets count decreased in cases group. - CLD increased in cases group.