Synthesis and evaluation of Pyrazole and Pyrazolone derivatives as corrosion inhibitors for copper in alkaline medium and their biological activity.

Abstract

The chemistry of pyrazoles has gained increasing attention due to its diverse pharmacological properties such as antiviral, antagonist, antimicrobial, anticancer, anti-inflammatory, analgesic, anti-prostate cancer, herbicidal, acaricidal and insecticidal activities. The starting material enaminonitriles (1a,b) were prepared according to a previously reported method. Treatment of (1a) with acetic anhydride, Ac2O/AcOH mixture, benzoyl chloride and/or phthalic anhydride afforded N,N-diacetyl pyrazole (2), pyrazolopyrimidine (3), N-benzoyl pyrazole (4) and 1,3-dioxoisoindolinyl pyrazole (5) derivatives respectively. (Scheme 1)