The effect of different plasma volume substitutes on systemic inflammatory . response in intensive care patients after major abdominal cancer surgery

Abstract

Surgical traumatic injury induces profound alterations in circulatory homeostasis and depression of cell mediated and humoral immunity. These sequelae predispose to sepsis and the systemic inflammatory response syndrome and even multiple organ failure.

These effects have been supposed to be due to increased levels of circulating adhesion molecules and proinflammatory cytokines. They seem to be good markers of endothelial damage, but they also have other biological functions.

The aim of this study is to shed light on the effect of different plasma volume expanders used in postoperative period on proinflammatory cytokines, adhesion molecules, laboratory and vital changes.

The study was conducted on 90 postoperative patients operated for major abdominal cancer surgery. They were divided into 3 groups according to the type of fluid therapy given: • Hydroxyethyl starch group (HES)

• Dextran 70% group

• Crystalloids group

Each group included 30patients.