Percutaneous Transluminal Angioplasty with Adjunctive Stenting for Peripheral Arterial Occlusive Disease: A Comparative Study of Iliac and Infrainguinal Arterial Intervention.

Abstract

Percutaneous transluminal angioplasty (PTA) has been developed as a less invasive revascularization procedure and it has proved to be an effective technique for the treatment of PAOD. Currently, the primary indications for an interventional procedure in patients with lower extremity arterial disease include incapacitating claudication interfering with lifestyle and limb-threatening ischemia.

The rapid evolution of stent design, deployment.approaches and adjunctive therapy made the practice of PTA safer and more predictable and has reduced the incidence of procedure related adverse events, particularly the need for emergency surgery.

Balloon angioplasty and stenting induces a vascular inflammatory response at the dilated vessel segment and a postinterventional increase of serum CRP. This vascular inflammatory process is associated with vascular-smooth muscle cell proliferation aml late neointimal growth. The extent of the vascular inflammatory response may therefore be related to intermediate and long term outcome of percutaneous transluminal angioplasty and stenting.

This study was designed to accomplish the following:

Determine the early and intermediate - term results of angioplasty with adjunctive stenting for peripheral arterial occlusive disease (PAOD) of the lower extremities. Assess the clinical, angiographic and procedural factors affecting intermediate tP,rm outcome.