Synthesis of Some Heterocyclic Compounds with Non-Mixed and Mixed Systems and Relevant Compounds

Abstract

The thesis includes two parts: Part I: Synthesis and reactions of 4-(4-ethylphenyl) or/and 4-(biphen-4-yl) phthalazine -1(2H)-one.  Reaction of 2-(4-ethylbenzoyl) and /or 2-(biphen-4-yl) benzoic acid (1a-b) with hydrazine hydrate in boiling ethanol afforded compounds (2a-b).  Reaction of compound (2a) with chloro acetyl chloride in pyridine afforded compound (3).  Reaction of compound (2a) with Allyl bromide in dioxane afforded compound (4).  Reaction of compound (2b) with chloro ethanol in ethanol afforded compound (5).  Reaction of compound (5) with resorcinol, catechol, hydroquinone, 2-hydroxy benzoic acid and pyrazine-1(4H)-carboxylic acid in boiling ethanol afforded compounds (6a-e).  Reaction of compound (6b) with acetic anhydride in dry acetone afforded compound (7).  Reaction of compound (2a) with phenyl isothiocyanate in benzene afforded compound (8).