Assessment of Serum Level Cholinesterase as a Biomarker of Post Viral Liver Cirrhosis

Abstract

SUMMARY C hronic liver diseases and cirrhosis are now being recognized as an important cause of morbidity and mortality worldwide. Established cirrhosis has a 10-year mortality of 34-66%. Hepatorenal syndrome and spontaneous bacterial peritonitis are important cause of mortality in cirrhosis. Cirrhotic patients frequently evaluated for the presence of such complications by using old methods namely Child-Pugh and MELD scores, and due to some shortages in MELD score with short survival rate within 3 months making a medical burden due to finding a new class of biomarkers. The aim of the present study was to evaluate serum cholinesterase as a biomarker in patients with liver cirrhosis. The study included 60 patients with liver cirrhosis, 20 patients hepatic non cirrhotic and 10 normal healthy persons. All were subjected to clinical evaluation, a group of laboratory investigations including complete blood count, liver and kidney function tests, coagulation profile, serum Na and K levels, serum cholinesterase level, and abdominal ultrasonography and calculation of both Child score and MELD score. We externally validated serum cholinesterase for evaluation of its prognostic potency in a relatively large group of patients with cirrhosis.