Role of Genetic Alternation in Predicting Disease Progression in B-Chronic Lymphocytic Leukemia
Gelan Hosny Abbas Abdel Kader;
Abstract
T
he B-cell chronic lymphocytic leukemia (CLL) is a disease with a very low proliferative activity. It is characterized by the accumulation of clonal B-lymphocytes that showed to be arrested in G0/G1 phase of the cell-cycle. Although the pathogenesis of B-CLL remains largely unknown, several investigators have focused on the role of cytogenetic aberrations that may contribute to defective apoptosis, deregulation of cell-cycle regulatory genes and expansion of the malignant clone.
Despite its homogeneity at cellular level, B-CLL is clinically heterogeneous. Some patients survive for a long-time without therapy, while others progress towards more advanced stages and die despite aggressive treatment. Reliable prognostic markers capable of predicting the progression of the disease include chromosomal analysis by interphase FISH, CD38 expression, ZAP-70, LDT, Smear cell and examination of bone marrow infiltration pattern.
he B-cell chronic lymphocytic leukemia (CLL) is a disease with a very low proliferative activity. It is characterized by the accumulation of clonal B-lymphocytes that showed to be arrested in G0/G1 phase of the cell-cycle. Although the pathogenesis of B-CLL remains largely unknown, several investigators have focused on the role of cytogenetic aberrations that may contribute to defective apoptosis, deregulation of cell-cycle regulatory genes and expansion of the malignant clone.
Despite its homogeneity at cellular level, B-CLL is clinically heterogeneous. Some patients survive for a long-time without therapy, while others progress towards more advanced stages and die despite aggressive treatment. Reliable prognostic markers capable of predicting the progression of the disease include chromosomal analysis by interphase FISH, CD38 expression, ZAP-70, LDT, Smear cell and examination of bone marrow infiltration pattern.
Other data
| Title | Role of Genetic Alternation in Predicting Disease Progression in B-Chronic Lymphocytic Leukemia | Other Titles | دور التحول الجينى في التنبؤ بتقدم المرض فى حالات سرطان الدم الليمفاوى المزمن بى | Authors | Gelan Hosny Abbas Abdel Kader | Issue Date | 2017 |
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