Circulating Endothelial Cells (CD146) in Sickle Cell Disease
Ayman Saad Ali Mahmoud;
Abstract
T
he aim of current study was to evaluate circulating endothelial cells (CD146%) and their relationship to cardiovascular dysfunction in patients with sickle cell disease.
This cross sectional study was conducted at the Pediatric Hematology clinic, Pediatric Hospital; Ain Shams University in the period from December 2013 to December 2014. The study involved 30 patients with sickle cell disease (group I). Their age ranged from 2 to 21years, including 66.7% males and 33.3% females, 66.7% sickle and 33.3% sickle thalassemia. Age at disease onset ranged from 0.5 to 4.5 years and duration of disease from 0.6 – 19.5 years. Patients (group I) were subdivided according to CD146% into two subgroups: (Ia) patients with CD 146% >0.22 and (Ib) those with CD 146% <0.22. The best cut off point between patients and control groups regarding CD146% was found > 0.22%. They were compared to 30 age- and sex-matched healthy subjects as a control group (group II) with age ranged from 1.5 to 13 years, including 66.7% males and 33.3% females.
he aim of current study was to evaluate circulating endothelial cells (CD146%) and their relationship to cardiovascular dysfunction in patients with sickle cell disease.
This cross sectional study was conducted at the Pediatric Hematology clinic, Pediatric Hospital; Ain Shams University in the period from December 2013 to December 2014. The study involved 30 patients with sickle cell disease (group I). Their age ranged from 2 to 21years, including 66.7% males and 33.3% females, 66.7% sickle and 33.3% sickle thalassemia. Age at disease onset ranged from 0.5 to 4.5 years and duration of disease from 0.6 – 19.5 years. Patients (group I) were subdivided according to CD146% into two subgroups: (Ia) patients with CD 146% >0.22 and (Ib) those with CD 146% <0.22. The best cut off point between patients and control groups regarding CD146% was found > 0.22%. They were compared to 30 age- and sex-matched healthy subjects as a control group (group II) with age ranged from 1.5 to 13 years, including 66.7% males and 33.3% females.
Other data
| Title | Circulating Endothelial Cells (CD146) in Sickle Cell Disease | Other Titles | الخلايا الأصلية البطانية العائمة(CD146) في المرضى الذين يعانون من مرض فقر الدم المنجلي | Authors | Ayman Saad Ali Mahmoud | Issue Date | 2017 |
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