Role of Melatonin in Reducing Hypoxia-Induced Oxidative Stress
Hala Abdel Fattah Mohamed;
Abstract
The present work was performed to study the protective effect of melatonin as an antioxidant and free radical scavenger on the oxidative stress and morphological changes induced by oxygen shortage (hypoxia) of male Swiss albino mice. In this study: the oxidized lipids of the liver, lung and testes homogenates, as well as the morphological changes of the liver, lung and testes were examined.
The 11resent work included two experiments
Experiment 1: In this experiment, the mice were randomly divided into three groups:
- The first group: (6 mice) was subjected to oxygen shortage
(hypoxia) for three hours and designated (Hypox).
- The second group: (8 mice) was subcutaneously injected with Melatonin (I 0 mg/kg body weight) 30 minutes before subjection to hypoxia for three hours and designated (Hypox+M).
- The third group: (6 mice) was kept as a control and left in the normal conditions.
The 11resent work included two experiments
Experiment 1: In this experiment, the mice were randomly divided into three groups:
- The first group: (6 mice) was subjected to oxygen shortage
(hypoxia) for three hours and designated (Hypox).
- The second group: (8 mice) was subcutaneously injected with Melatonin (I 0 mg/kg body weight) 30 minutes before subjection to hypoxia for three hours and designated (Hypox+M).
- The third group: (6 mice) was kept as a control and left in the normal conditions.
Other data
| Title | Role of Melatonin in Reducing Hypoxia-Induced Oxidative Stress | Other Titles | دور الميلاتونين فى اختزال جهد الأكسدة المستحدث بنقص الاكسجين | Authors | Hala Abdel Fattah Mohamed | Issue Date | 2005 |
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