Stem Cell Therapy in Surgical Practice
Mohamed Mohamed Saeed Mady;
Abstract
The field of stem cells, tissue engineering, and regenerative medicine is rapidly moving toward translation to clinical application. Stem cells therapy enters all the surgical and medical fields giving a new hope for doctors and patients.
Stem cells are undifferentiated cells that are defined by their ability of both self-renewal and differentiation.
There are many types of stem cells, differing in their degree of differentiation (plasticity) and sources. Gametes cells (eggs or sperms), Embryonic stem cells, Adult stem cells, Induced pluripotent stem cells and Cancer stem cells.
All stem cells, regardless of their source, have three general properties: They are capable of dividing and renewing themselves for long periods; they are unspecialized; and they can give rise to specialized cell types.
Isolation of stem cells can be a delicate and multistep process whether from blastocytes or somatic tissues. Protocols may also need to be adjusted based on the stem cell source or species.
Intestinal stem cells’ growth and differentiation may stimulate new approaches for tissue engineering of both the small and the large intestine for short bowel syndrome, total colectomy, abdominoperineal resection, intractable fecalincontinence or congenital anorectal malformations.
An advantage of using stem cells to treat an anal fistula is that, because tract resection is not required, the treatment does not injure the anal sphincter. stem cells have been used to treat complex anal fistulas, either cryptoglandular or Crohn's fistulas and rectovaginal fistulas in patients with Crohn’s disease.
Stem cells injection may represent a new attractive treatment option for anal sphincter lesions and anal incontinence.
Stem cell-based therapy has a promising role intreating acute renal injury, stress urinary incontinence and urinary bladder reconstruction.
In the field of musculoskeletal injuries, stem cell therapy proved to be effective in bone, cartilage, tendons and muscles regeneration.
Stem cell therapy can be the the right direction for treatment of some endocrinal disorders. stem cells could be of major interest in the treatment of congenital or acquired hypopituitarism and regeneration of thyrocytes.
Stem cell therapy gained momentum to engineer islet-like cells or insulin producing cells from different types of stem cells.
Stem cells are used to solves theproblem of tissue rejection and graft-versus-host disease.
Stem cells, cellular therapies and regenerative medicine have a central role for plastic and reconstructive surgery applications as breast augmentation and reconstruction, facial rejuvenation, soft-tissue reconstruction
Stem cells have been used for the production of tissue engineered vascular grafts, peripheral arterial disease, critical limb ischaemia, Buerger's disease, venous thrombi and Infantile hemangioma.
Stem cells are undifferentiated cells that are defined by their ability of both self-renewal and differentiation.
There are many types of stem cells, differing in their degree of differentiation (plasticity) and sources. Gametes cells (eggs or sperms), Embryonic stem cells, Adult stem cells, Induced pluripotent stem cells and Cancer stem cells.
All stem cells, regardless of their source, have three general properties: They are capable of dividing and renewing themselves for long periods; they are unspecialized; and they can give rise to specialized cell types.
Isolation of stem cells can be a delicate and multistep process whether from blastocytes or somatic tissues. Protocols may also need to be adjusted based on the stem cell source or species.
Intestinal stem cells’ growth and differentiation may stimulate new approaches for tissue engineering of both the small and the large intestine for short bowel syndrome, total colectomy, abdominoperineal resection, intractable fecalincontinence or congenital anorectal malformations.
An advantage of using stem cells to treat an anal fistula is that, because tract resection is not required, the treatment does not injure the anal sphincter. stem cells have been used to treat complex anal fistulas, either cryptoglandular or Crohn's fistulas and rectovaginal fistulas in patients with Crohn’s disease.
Stem cells injection may represent a new attractive treatment option for anal sphincter lesions and anal incontinence.
Stem cell-based therapy has a promising role intreating acute renal injury, stress urinary incontinence and urinary bladder reconstruction.
In the field of musculoskeletal injuries, stem cell therapy proved to be effective in bone, cartilage, tendons and muscles regeneration.
Stem cell therapy can be the the right direction for treatment of some endocrinal disorders. stem cells could be of major interest in the treatment of congenital or acquired hypopituitarism and regeneration of thyrocytes.
Stem cell therapy gained momentum to engineer islet-like cells or insulin producing cells from different types of stem cells.
Stem cells are used to solves theproblem of tissue rejection and graft-versus-host disease.
Stem cells, cellular therapies and regenerative medicine have a central role for plastic and reconstructive surgery applications as breast augmentation and reconstruction, facial rejuvenation, soft-tissue reconstruction
Stem cells have been used for the production of tissue engineered vascular grafts, peripheral arterial disease, critical limb ischaemia, Buerger's disease, venous thrombi and Infantile hemangioma.
Other data
| Title | Stem Cell Therapy in Surgical Practice | Other Titles | العلاج بالخلية الجذعية فى المجال الجراحى | Authors | Mohamed Mohamed Saeed Mady | Issue Date | 2015 |
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