The Frequency of Androgen Excess in a Cross of Egyptian Wonen With Polycystic Ovary Syndrome

Abstract

Polycystic ovary syndrome (PCOS) is a common gynecological endocrinopathy affecting 6-8% of premenopausal women. Despite the diverse phenotypes, it is classically characterized by ovarian dysfunction (oligo-amenorrhea, anovulatory infertility) in conjunction with cardinal features of hyperandrogenism and polycystic ovary morphology. Emerging evidence suggests that PCOS should no longer be considered a purely gynecological disorder because of its predisposition to various cardiometabolic risk factors. These include hyperandrogenism, obesity, glucose intolerance, atherogenic dyslipidemia, and hypertension. The study was designed on eighty female patients with PCOS; single venous blood sample was drawn from the PCOS patients for measurement of serum total testosterone and SHBG and calculation of free androgen index. The aim of this study was to evaluate the prevalence of hyperandrogenemia in Egyptian women with PCOS, and hence predict the subsequent risk in such patients and also detect lines of treatment According to this study the prevalence of hyperandrogenemia among the Egyptian women with PCOS was 91.3% and the most common symptom was hirsutism . Also this study revealed that FAI is a useful diagnostic parameter for the assessment of hyperandrgenemia. This study revealed that hyperandrogenemia was a risk factor for the metabolic syndrome .